Title: | (Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice |
Authors: | Fukushima, Arata Browse this author →KAKEN DB |
Kinugawa, Shintaro Browse this author →KAKEN DB |
Takada, Shingo Browse this author →KAKEN DB |
Matsushima, Shouji Browse this author →KAKEN DB |
Sobirin, Mochamad Ali Browse this author |
Ono, Taisuke Browse this author |
Takahashi, Masashige Browse this author |
Suga, Tadashi Browse this author |
Homma, Tsuneaki Browse this author |
Masaki, Yoshihiro Browse this author |
Furihata, Takaaki Browse this author |
Kadoguchi, Tomoyasu Browse this author |
Yokota, Takashi Browse this author →KAKEN DB |
Okita, Koichi Browse this author →KAKEN DB |
Tsutsui, Hiroyuki Browse this author →KAKEN DB |
Keywords: | (pro)renin receptor |
renin-angiotensin system |
oxidative stress |
insulin resistance |
heart failure |
Issue Date: | 2014 |
Publisher: | American Physiological Society |
Journal Title: | American Journal of Physiology-Endocrinology and Metabolism |
Volume: | 307 |
Issue: | 6 |
Start Page: | E503 |
End Page: | E514 |
Publisher DOI: | 10.1152/ajpendo.00449.2013 |
Abstract: | We previously reported that insulin resistance was induced by the impairment of insulin signaling in the skeletal muscle from heart failure (HF) via NAD(P)H oxidase-dependent oxidative stress. (Pro)renin receptor [(P)RR] is involved in the activation of local renin-angiotensin system and subsequent oxidative stress. We thus examined whether (P)RR inhibitor, handle region peptide (HRP), could ameliorate insulin resistance in HF after myocardial infarction (MI) by improving oxidative stress and insulin signaling in the skeletal muscle. C57BL6J mice were divided into four groups: sham operated (Sham, n = 10), Sham treated with HRP (Sham+HRP, 0.1 mg·kg−1·day−1, n = 10), MI operated (MI, n = 10), and MI treated with HRP (MI+HRP, 0.1 mg/kg/day, n = 10). After 4 wk, MI mice showed left ventricular dysfunction, which was not affected by HRP. (P)RR was upregulated in the skeletal muscle after MI (149% of sham, P < 0.05). The decrease in plasma glucose after insulin load was smaller in MI than in Sham (21 ± 2 vs. 44 ± 3%, P < 0.05), and was greater in MI+HRP (38 ± 2%, P < 0.05) than in MI. Insulin-stimulated serine phosphorylation of Akt and glucose transporter 4 translocation were decreased in the skeletal muscle from MI by 48 and 49% of Sham, both of which were ameliorated in MI+HRP. Superoxide production and NAD(P)H oxidase activities were increased in MI, which was inhibited in MI+HRP. HRP ameliorated insulin resistance associated with HF by improving insulin signaling via the inhibition of NAD(P)H oxidase-induced superoxide production in the skeletal muscle. The (P)RR pathway is involved in the development of insulin resistance, at least in part, via the impairment of insulin signaling in the skeletal muscle from HF. |
Type: | article |
URI: | http://hdl.handle.net/2115/76770 |
Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|