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Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver

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Title: Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver
Authors: Fujii, Yuki Browse this author
Kawamura, Norio Browse this author →KAKEN DB
Zaitsu, Masaaki Browse this author →KAKEN DB
Watanabe, Masaaki Browse this author →KAKEN DB
Goto, Ryoichi Browse this author →KAKEN DB
Kamiyama, Toshiya Browse this author →KAKEN DB
Taketomi, Akinobu Browse this author →KAKEN DB
Shimamura, Tsuyoshi Browse this author →KAKEN DB
Keywords: Diet Therapy
Fatty Liver
Liver Transplantation
Living Donors
Issue Date: 10-Jan-2020
Publisher: International Scientific Information, Inc.
Journal Title: Annals of transplantation
Volume: 25
Start Page: UNSP e920677
Publisher DOI: 10.12659/AOT.920677
Abstract: Background: The aim of this study was to determine the efficacy of treating donors' fatty liver (FL) and to assess early graft function in recipients who received treated FL grafts in living-donor liver transplantation (LDLT). Material/Methods: Data were collected for adult-to-adult LDLTs. Donors diagnosed with FL (FL group) received diet-exercise and pharmacological treatment. The perioperative findings and early transplanted graft function were compared with those of donors without FL (non-FL group) during the same period. Results: Of 30 donors, 8 were determined to have FL The median duration of treatment for FL was 58 days. The liver-to- spleen attenuation ratios on CT scan in the FL group were significantly improved after treatment: 0.95 (0.62-1.06) to 1.2 (1.12-1.46) (P=0.003). Liver biopsy prior to donor surgery showed <= 10% fatty infiltration. Postoperative laboratory findings of the donors in the FL group were comparable to those in the non-FL group: maximum alanine transaminase (189.6 +/- 94.7 IU/L vs. 196.8 +/- 57.4) and maximum total bilirubin (2.2 +/- 1.1 mg/dl vs. 1.7 +/- 0.5 mg/dL). No major complications were observed after donor hepatectomy in either group. There were no significant differences between the 2 groups in early graft function, as evaluated by laboratory data, ascites volume, and bile production 2 weeks postoperatively. Graft and patient survival were 100% in both groups at 3 months. Conclusions: Preoperative intentional treatment for FL was effective. Early graft function and donor postoperative course were comparable in the 2 groups. These results suggest that well-treated steatotic grafts can be used without jeopardizing donor safety.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/76802
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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