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Questiomycins, Algicidal Compounds Produced by the Marine Bacterium Alteromonas sp. D and their Production Cue

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Title: Questiomycins, Algicidal Compounds Produced by the Marine Bacterium Alteromonas sp. D and their Production Cue
Authors: Umetsu, Saki Browse this author
Kanda, Mamoru Browse this author
Imai, Ichiro Browse this author →KAKEN DB
Sakai, Ryuichi Browse this author →KAKEN DB
Fujita, Masaki J. Browse this author →KAKEN DB
Keywords: algicidal bacteria
questiomycins
phenoxazinone antibiotics
Alteromonas
Chattonella antiqua
harmful algal bloom
red tide
Issue Date: 10-Dec-2019
Publisher: MDPI
Journal Title: Molecules
Volume: 24
Issue: 24
Start Page: 4522
Publisher DOI: 10.3390/molecules24244522
Abstract: Questiomycin A (1) along with three new compounds, questiomycins C-E (2-4), were isolated from culture of Alteromonas sp. D, an algicidal marine bacterium, guided by algal lethality assay using the raphidophyte, Chattonella antiqua, one of the causative organisms of harmful algal bloom. The structures of 1-4 were assigned on the basis of their spectrometric and spectroscopic data. Compounds 1 to 4 exhibited algicidal activity against C. antiqua with LC50 values ranging from 0.18 to 6.37 mu M. Co-cultivation experiment revealed that 1 was produced only when the microalgae and the bacterium are in close contact, suggesting that some interactions between them trigger the biosynthesis of questiomycins. These results suggested that the algicidal bacteria such as Alteromonas sp. D can control microalgae chemically in marine ecosystem.
Rights: https://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/76811
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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