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Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/76826

Title: Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus
Authors: Fujieda, Yuichiro Browse this author →KAKEN DB
Mader, Simone Browse this author
Jeganathan, Venkatesh Browse this author
Arinuma, Yoshiyuki Browse this author
Shimizu, Yuka Browse this author
Kato, Masaru Browse this author
Oku, Kenji Browse this author
Minami, Akiko Browse this author
Shimizu, Chikara Browse this author →KAKEN DB
Yasuda, Shinsuke Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: anti-NR2 antibody
neuropsychiatric systemic lupus erythematosus
N-methyl D-aspartate receptors
post-steroid neuropsychiatric manifestation
systemic lupus erythematosus
Issue Date: Mar-2019
Publisher: John Wiley & Sons
Journal Title: International journal of rheumatic diseases
Volume: 22
Issue: 3
Start Page: 443
End Page: 448
Publisher DOI: 10.1111/1756-185X.13392
PMID: 30358102
Abstract: Background Anti-DNA/N-methyl-D-aspartate receptor 2 (NR2) antibodies (anti-DNA/NR2 antibodies) are a subset of anti-DNA autoantibodies that cross-react with the extracellular domain of the GluN2A/GluN2B subunits of NR2. These antibodies induce apoptosis of hippocampus neurons and psychiatric disorder in mice and humans. Neuropsychiatric system lupus erythematosus (NPSLE) can develop after initiation of corticosteroids (post-steroid neuropsychiatric manifestation: PSNP) or before treatment (de novo NPSLE); however, pathophysiological differences between these subtypes remain unclear. The objective of this study was to clarify the prevalence of anti-DNA/NR2 antibodies in patients with NPSLE. Methods This study involved a cohort of patients with NPSLE admitted to our hospital. NPSLE patients were classified into two groups, de novo NPSLE and PSNP-SLE. Serum anti-DNA antibodies and anti-DNA/NR2 antibodies were measured by enzyme-linked immunosorbent assays. Results Serum samples were obtained from 24 patients with de novo NPSLE, 25 with PSNP-SLE and 76 healthy controls (HC). The level of anti-DNA/NR2 antibodies in patients with de novo NPSLE and PSNP-SLE were also higher than those in HC. Positive correlation between anti-DNA antibodies and anti-DNA/NR2 antibodies were found in PSNP-SLE, but was not significant in de novo NPSLE. Conclusion The levels of anti-DNA/NR2 antibodies in PSNP-SLE were similar to those in de novo NPSLE. Anti-DNA/NR2 antibodies in PSNP-SLE were suggested as a dominant subset of anti-DNA antibodies, indicating that anti-DNA/NR2 antibodies may be a predictive factor in PSNP-SLE.
Rights: This is the peer reviewed version of the following article: International journal of rheumatic diseases. 2019, 22(3), 443-448, which has been published in final form at https://doi.org/10.1111/1756-185X.13392. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
URI: http://hdl.handle.net/2115/76826
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤枝 雄一郎

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