| Title: | Clinical significance of anti-DNA/N-methyl-D-aspartate receptor 2 antibodies in de novo and post-steroid cases with neuropsychiatric systemic lupus erythematosus |
| Authors: | Fujieda, Yuichiro Browse this author →KAKEN DB |
| Mader, Simone Browse this author |
| Jeganathan, Venkatesh Browse this author |
| Arinuma, Yoshiyuki Browse this author |
| Shimizu, Yuka Browse this author |
| Kato, Masaru Browse this author |
| Oku, Kenji Browse this author |
| Minami, Akiko Browse this author |
| Shimizu, Chikara Browse this author →KAKEN DB |
| Yasuda, Shinsuke Browse this author →KAKEN DB |
| Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | anti-NR2 antibody |
| neuropsychiatric systemic lupus erythematosus |
| N-methyl D-aspartate receptors |
| post-steroid neuropsychiatric manifestation |
| systemic lupus erythematosus |
| Issue Date: | Mar-2019 |
| Publisher: | John Wiley & Sons |
| Journal Title: | International journal of rheumatic diseases |
| Volume: | 22 |
| Issue: | 3 |
| Start Page: | 443 |
| End Page: | 448 |
| Publisher DOI: | 10.1111/1756-185X.13392 |
| PMID: | 30358102 |
| Abstract: | Background Anti-DNA/N-methyl-D-aspartate receptor 2 (NR2) antibodies (anti-DNA/NR2 antibodies) are a subset of anti-DNA autoantibodies that cross-react with the extracellular domain of the GluN2A/GluN2B subunits of NR2. These antibodies induce apoptosis of hippocampus neurons and psychiatric disorder in mice and humans. Neuropsychiatric system lupus erythematosus (NPSLE) can develop after initiation of corticosteroids (post-steroid neuropsychiatric manifestation: PSNP) or before treatment (de novo NPSLE); however, pathophysiological differences between these subtypes remain unclear. The objective of this study was to clarify the prevalence of anti-DNA/NR2 antibodies in patients with NPSLE. Methods This study involved a cohort of patients with NPSLE admitted to our hospital. NPSLE patients were classified into two groups, de novo NPSLE and PSNP-SLE. Serum anti-DNA antibodies and anti-DNA/NR2 antibodies were measured by enzyme-linked immunosorbent assays. Results Serum samples were obtained from 24 patients with de novo NPSLE, 25 with PSNP-SLE and 76 healthy controls (HC). The level of anti-DNA/NR2 antibodies in patients with de novo NPSLE and PSNP-SLE were also higher than those in HC. Positive correlation between anti-DNA antibodies and anti-DNA/NR2 antibodies were found in PSNP-SLE, but was not significant in de novo NPSLE. Conclusion The levels of anti-DNA/NR2 antibodies in PSNP-SLE were similar to those in de novo NPSLE. Anti-DNA/NR2 antibodies in PSNP-SLE were suggested as a dominant subset of anti-DNA antibodies, indicating that anti-DNA/NR2 antibodies may be a predictive factor in PSNP-SLE. |
| Rights: | This is the peer reviewed version of the following article: International journal of rheumatic diseases. 2019, 22(3), 443-448, which has been published in final form at https://doi.org/10.1111/1756-185X.13392. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/76826 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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