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Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5′- and 3′-UTRs

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Title: Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5′- and 3′-UTRs
Authors: Yasuda, Motoaki Browse this author →KAKEN DB
Hatanaka, Tomoyuki Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Nishioka, Takeshi Browse this author →KAKEN DB
Keywords: Hypoxia
Issue Date: 16-May-2014
Publisher: Elsevier
Journal Title: Biochemical and Biophysical Research Communications
Volume: 447
Issue: 4
Start Page: 638
End Page: 643
Publisher DOI: 10.1016/j.bbrc.2014.04.058
PMID: 24769203
Abstract: In the present study, we demonstrated the reciprocal regulation of hypoxia-inducible factor 1 alpha (HIF1A) gene expression via untranslated region-(UTR) dependent mechanisms. A 151 nucleotide sequence found in the HIF1A 5′-UTR is sufficient for significant translational up-regulation. On the other hand, the 3′-UTR of HIF1A has been implicated in mRNA degradation. In the non-metastatic breast cancer cell line MCF7, the 3′-UTR-dependent down-regulatory machinery predominates over the 5′-UTR-dependent up-regulation of HIF1A. However, 5′-UTR-dependent up-regulation is dominant among metastatic cell lines (MDA-MB453, U87MG). It is therefore likely that the predominance of 5′-UTR-dependent translational enhancement of HIF1A is critical for the malignant phenotype of cancer cells. PTBP-1, but not HuR, is a candidate RNA binding protein for the translational control of HIF1A.
Rights: © <2014>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 安田 元昭

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