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Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense

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Title: Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense
Authors: Suganuma, Keisuke Browse this author →KAKEN DB
Sarwono, Albertus Eka Yudistira Browse this author
Mitsuhashi, Shinya Browse this author →KAKEN DB
Jąkalski, Marcin Browse this author
Okada, Tadashi Browse this author
Nthatisi, Molefe Browse this author
Yamagishi, Junya Browse this author →KAKEN DB
Ubukata, Makoto Browse this author →KAKEN DB
Inoue, Noboru Browse this author →KAKEN DB
Issue Date: Jul-2016
Publisher: American Society for Microbiology
Journal Title: Antimicrobial agents and chemotherapy
Volume: 60
Issue: 7
Start Page: 4391
End Page: 4393
Publisher DOI: 10.1128/AAC.02816-15
PMID: 27139487
Abstract: This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense. The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs.
Type: article
URI: http://hdl.handle.net/2115/76882
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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