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Hokkaido University Collection of Scholarly and Academic Papers >
Global Institution for Collaborative Research and Education : GI-CoRE >
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Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense
| Title: | Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense |
| Authors: | Suganuma, Keisuke Browse this author →KAKEN DB | | Sarwono, Albertus Eka Yudistira Browse this author | | Mitsuhashi, Shinya Browse this author →KAKEN DB | | Jąkalski, Marcin Browse this author | | Okada, Tadashi Browse this author | | Nthatisi, Molefe Browse this author | | Yamagishi, Junya Browse this author →KAKEN DB | | Ubukata, Makoto Browse this author →KAKEN DB | | Inoue, Noboru Browse this author →KAKEN DB |
| Issue Date: | Jul-2016 |
| Publisher: | American Society for Microbiology |
| Journal Title: | Antimicrobial agents and chemotherapy |
| Volume: | 60 |
| Issue: | 7 |
| Start Page: | 4391 |
| End Page: | 4393 |
| Publisher DOI: | 10.1128/AAC.02816-15 |
| PMID: | 27139487 |
| Abstract: | This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense. The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives have the potential to be new candidates as novel trypanocidal drugs. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76882 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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