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Effect of Spirulina lipids on high-fat and high-sucrose diet induced obesity and hepatic lipid accumulation in C57BL/6J mice
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| Title: | Effect of Spirulina lipids on high-fat and high-sucrose diet induced obesity and hepatic lipid accumulation in C57BL/6J mice |
| Authors: | Yang, Yuhong Browse this author | | Du, Lei Browse this author | | Hosokawa, Masashi Browse this author →KAKEN DB | | Miyashita, Kazuo Browse this author →KAKEN DB |
| Keywords: | Spirulina lipids | | Fish oil | | Gamma-linolenic acid | | High-fat and high-sucrose diet | | Obesity | | Nonalcoholic fatty liver disease |
| Issue Date: | Feb-2020 |
| Publisher: | Elsevier |
| Journal Title: | Journal of functional foods |
| Volume: | 65 |
| Start Page: | 103741 |
| Publisher DOI: | 10.1016/j.jff.2019.103741 |
| Abstract: | Obesity is characterized by abnormal or excessive fat accumulation that impairs health. In this study, the effects of Spirulina lipids (SL) and fish oil (FO) on obesity and hepatic lipid accumulation in high-fat and high-sucrose diet induced obese C57BL/6J mice were evaluated and compared. After 12 weeks of feeding, 4% gamma-linolenic acid-enriched SL supplementation effectively reduced the gain of body weight, total white adipose tissue (WAT) weight and hepatic lipid levels in obese mice. Although dietary 4% FO also tended to suppress the increases of body weight and WAT weight in mice, no statistical difference was observed. The suppression of hepatic lipid accumulation by SL should be through regulating sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2-mediated triacylglycerol and cholesterol synthesis pathway as well as via enhancement of peroxisome proliferator-activated receptor alpha (PPAR alpha)-mediated beta-oxidation. These findings firstly confirmed that SL could alleviate diet-induced obesity and hepatic lipid accumulation. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76916 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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