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Effect of Spirulina lipids on high-fat and high-sucrose diet induced obesity and hepatic lipid accumulation in C57BL/6J mice

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Title: Effect of Spirulina lipids on high-fat and high-sucrose diet induced obesity and hepatic lipid accumulation in C57BL/6J mice
Authors: Yang, Yuhong Browse this author
Du, Lei Browse this author
Hosokawa, Masashi Browse this author →KAKEN DB
Miyashita, Kazuo Browse this author →KAKEN DB
Keywords: Spirulina lipids
Fish oil
Gamma-linolenic acid
High-fat and high-sucrose diet
Obesity
Nonalcoholic fatty liver disease
Issue Date: Feb-2020
Publisher: Elsevier
Journal Title: Journal of functional foods
Volume: 65
Start Page: 103741
Publisher DOI: 10.1016/j.jff.2019.103741
Abstract: Obesity is characterized by abnormal or excessive fat accumulation that impairs health. In this study, the effects of Spirulina lipids (SL) and fish oil (FO) on obesity and hepatic lipid accumulation in high-fat and high-sucrose diet induced obese C57BL/6J mice were evaluated and compared. After 12 weeks of feeding, 4% gamma-linolenic acid-enriched SL supplementation effectively reduced the gain of body weight, total white adipose tissue (WAT) weight and hepatic lipid levels in obese mice. Although dietary 4% FO also tended to suppress the increases of body weight and WAT weight in mice, no statistical difference was observed. The suppression of hepatic lipid accumulation by SL should be through regulating sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2-mediated triacylglycerol and cholesterol synthesis pathway as well as via enhancement of peroxisome proliferator-activated receptor alpha (PPAR alpha)-mediated beta-oxidation. These findings firstly confirmed that SL could alleviate diet-induced obesity and hepatic lipid accumulation.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/76916
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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