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Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Skeletal Muscle Function but Not with Muscle Mass in Patients with Heart Failure

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Title: Serum Brain-Derived Neurotrophic Factor Levels Are Associated with Skeletal Muscle Function but Not with Muscle Mass in Patients with Heart Failure
Authors: Nakano, Ippei Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Hori, Hiroaki Browse this author
Fukushima, Arata Browse this author →KAKEN DB
Yokota, Takashi Browse this author →KAKEN DB
Takada, Shingo Browse this author →KAKEN DB
Kakutani, Naoya Browse this author
Obata, Yoshikuni Browse this author
Yamanashi, Katsuma Browse this author
Anzai, Toshihisa Browse this author →KAKEN DB
Keywords: Muscle strength
Exercise capacity
Issue Date: Jan-2020
Publisher: International Heart Journal Association
Journal Title: International heart journal
Volume: 61
Issue: 1
Start Page: 96
End Page: 102
Publisher DOI: 10.1536/ihj.19-400
Abstract: Heart failure (HF) is associated with aberrant skeletal muscle impairments. which are closely linked to the severity of HE. A low level of brain-derived neurotrophic factor (BDNF), a myokine produced in the skeletal muscle, is known to be involved in reduced exercise capacity and poor prognosis in HF. However. little is known about the factors or conditions of skeletal muscle associated with BDNF levels. We investigated the association between serum BDNF levels and the skeletal muscle mass and function in HF patients (n = 60. 63 13 years) and age-matched controls (n = 29, 61 +/- 16 years). The serum BDNF level was significantly lower in the HF patients compared to the controls (24.9 +/- 0.9 versus 28.6 +/- 1.3, P = 0.021). In a univariate analysis, BDNF was significantly correlated with the peak oxygen uptake, estimated glomerular filtration rate, 10-m gait speed, and muscle strength, but not with the body mass index or lean mass in the HF group. A multiple linear regression analysis revealed that BDNF was independently associated with muscle strength beta-coefficient = 2.80, 95%CI: 1.89-11.8, P = 0.008). Serum BDNF levels were associated with exercise capacity and skeletal muscle function, but not with muscle mass. These novel findings may suggest that BDNF production is controlled by muscle function and activity and consequently regulates exercise capacity, highlighting the importance of adequate training regarding skeletal muscle in HF patients.
Type: article
URI: http://hdl.handle.net/2115/76918
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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