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Prenatal tobacco exposure and ADHD symptoms at pre-school age : the Hokkaido Study on Environment and Children's Health
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| Title: | Prenatal tobacco exposure and ADHD symptoms at pre-school age : the Hokkaido Study on Environment and Children's Health |
| Authors: | Minatoya, Machiko Browse this author →KAKEN DB | | Araki, Atsuko Browse this author →KAKEN DB | | Itoh, Sachiko Browse this author →KAKEN DB | | Yamazaki, Keiko Browse this author →KAKEN DB | | Kobayashi, Sumitaka Browse this author →KAKEN DB | | Miyashita, Chihiro Browse this author →KAKEN DB | | Sasaki, Seiko Browse this author →KAKEN DB | | Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | ADHD | | Prenatal tobacco exposure | | Passive smoking | | Birth cohort | | SDQ |
| Issue Date: | Dec-2019 |
| Publisher: | Springer |
| Journal Title: | Environmental Health and Preventive Medicine |
| Volume: | 24 |
| Issue: | 1 |
| Start Page: | 74 |
| Publisher DOI: | 10.1186/s12199-019-0834-4 |
| PMID: | 31812162 |
| Abstract: | Background There have been inconsistent findings reported on maternal passive smoking during pregnancy and child risk of ADHD. In this study, ADHD symptoms at pre-school age children in association with prenatal passive and active tobacco smoke exposure determined by maternal plasma cotinine levels in the third trimester were investigated. Methods This was a follow-up study of the birth cohort: the Hokkaido Study on Environment and Children's Health. Children whose parents answered Strengths and Difficulties Questionnaire (SDQ) to identify child ADHD symptoms (hyperactivity/inattention and conduct problems) and total difficulties at age 5 years with available maternal plasma cotinine level at the third trimester were included (n = 3216). Cotinine levels were categorized into 4 groups; <= 0.21 ng/ml (non-smoker), 0.22-0.51 ng/ml (low-passive smoker), 0.52-11.48 ng/ml (high-passive smoker), and >= 11.49 ng/ml (active smoker). Results Maternal cotinine levels of active smokers were significantly associated with an increased risk of total difficulties (OR = 1.67) and maternal low- and high-passive smoking also increased the risk (OR = 1.11, 1.25, respectively) without statistical significance. Similarly, maternal cotinine levels of active smokers were associated with an increased risk of hyperactivity/inattention (OR = 1.49). Maternal low- and high-passive smoking and active smoking increased the risk of hyperactivity/inattention (OR = 1.45, 1.43, and OR = 1.59, respectively) only in boys. Conclusion Our findings suggested that maternal active smoking during pregnancy may contribute to the increased risk of child total difficulties and hyperactivity/inattention at pre-school age. Pregnant women should be encouraged to quit smoking and avoid exposure to tobacco smoke. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76919 |
| Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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