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Prenatal tobacco exposure and ADHD symptoms at pre-school age : the Hokkaido Study on Environment and Children's Health

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Title: Prenatal tobacco exposure and ADHD symptoms at pre-school age : the Hokkaido Study on Environment and Children's Health
Authors: Minatoya, Machiko Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Yamazaki, Keiko Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: ADHD
Prenatal tobacco exposure
Passive smoking
Birth cohort
Issue Date: Dec-2019
Publisher: Springer
Journal Title: Environmental Health and Preventive Medicine
Volume: 24
Issue: 1
Start Page: 74
Publisher DOI: 10.1186/s12199-019-0834-4
PMID: 31812162
Abstract: Background There have been inconsistent findings reported on maternal passive smoking during pregnancy and child risk of ADHD. In this study, ADHD symptoms at pre-school age children in association with prenatal passive and active tobacco smoke exposure determined by maternal plasma cotinine levels in the third trimester were investigated. Methods This was a follow-up study of the birth cohort: the Hokkaido Study on Environment and Children's Health. Children whose parents answered Strengths and Difficulties Questionnaire (SDQ) to identify child ADHD symptoms (hyperactivity/inattention and conduct problems) and total difficulties at age 5 years with available maternal plasma cotinine level at the third trimester were included (n = 3216). Cotinine levels were categorized into 4 groups; <= 0.21 ng/ml (non-smoker), 0.22-0.51 ng/ml (low-passive smoker), 0.52-11.48 ng/ml (high-passive smoker), and >= 11.49 ng/ml (active smoker). Results Maternal cotinine levels of active smokers were significantly associated with an increased risk of total difficulties (OR = 1.67) and maternal low- and high-passive smoking also increased the risk (OR = 1.11, 1.25, respectively) without statistical significance. Similarly, maternal cotinine levels of active smokers were associated with an increased risk of hyperactivity/inattention (OR = 1.49). Maternal low- and high-passive smoking and active smoking increased the risk of hyperactivity/inattention (OR = 1.45, 1.43, and OR = 1.59, respectively) only in boys. Conclusion Our findings suggested that maternal active smoking during pregnancy may contribute to the increased risk of child total difficulties and hyperactivity/inattention at pre-school age. Pregnant women should be encouraged to quit smoking and avoid exposure to tobacco smoke.
Type: article
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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