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Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

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Title: Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
Authors: Takadate, Yoshihiro Browse this author
Kondoh, Tatsunari Browse this author
Igarashi, Manabu Browse this author →KAKEN DB
Maruyama, Junki Browse this author
Manzoor, Rashid Browse this author
Ogawa, Hirohito Browse this author →KAKEN DB
Kajihara, Masahiro Browse this author →KAKEN DB
Furuyama, Wakako Browse this author
Sato, Masahiro Browse this author
Miyamoto, Hiroko Browse this author
Yoshida, Reiko Browse this author
Hill, Terence E. Browse this author
Freiberg, Alexander N. Browse this author
Feldmann, Heinz Browse this author
Marzi, Andrea Browse this author
Takada, Ayato Browse this author →KAKEN DB
Issue Date: 14-Jan-2020
Publisher: Cell Press
Journal Title: Cell Reports
Volume: 30
Issue: 2
Start Page: 308
End Page: 319.e5
Publisher DOI: 10.1016/j.celrep.2019.12.042
PMID: 31940478
Abstract: Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species. Here, we show a molecular basis underlying the host-range restriction of filoviruses. We find that bat-derived cell lines FBKT1 and ZFBK13-76E show preferential susceptibility to EBOV and MARV, respectively, whereas the other bat cell lines tested are similarly infected with both viruses. In FBKT1 and ZFBK13-76E, unique amino acid (aa) sequences are found in the Niemann-Pick C1 (NPC1) protein, one of the cellular receptors interacting with the filovirus glycoprotein (GP). These aa residues, as well as a few aa differences between EBOV and MARV GPs, are crucial for the differential susceptibility to filoviruses. Taken together, our findings indicate that the heterogeneity of bat NPC1 orthologs is an important factor controlling filovirus species-specific host tropism.
Type: article
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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