Title: | Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism |
Authors: | Takadate, Yoshihiro Browse this author |
Kondoh, Tatsunari Browse this author |
Igarashi, Manabu Browse this author →KAKEN DB |
Maruyama, Junki Browse this author |
Manzoor, Rashid Browse this author |
Ogawa, Hirohito Browse this author →KAKEN DB |
Kajihara, Masahiro Browse this author →KAKEN DB |
Furuyama, Wakako Browse this author |
Sato, Masahiro Browse this author |
Miyamoto, Hiroko Browse this author |
Yoshida, Reiko Browse this author |
Hill, Terence E. Browse this author |
Freiberg, Alexander N. Browse this author |
Feldmann, Heinz Browse this author |
Marzi, Andrea Browse this author |
Takada, Ayato Browse this author →KAKEN DB |
Issue Date: | 14-Jan-2020 |
Publisher: | Cell Press |
Journal Title: | Cell Reports |
Volume: | 30 |
Issue: | 2 |
Start Page: | 308 |
End Page: | 319.e5 |
Publisher DOI: | 10.1016/j.celrep.2019.12.042 |
PMID: | 31940478 |
Abstract: | Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species. Here, we show a molecular basis underlying the host-range restriction of filoviruses. We find that bat-derived cell lines FBKT1 and ZFBK13-76E show preferential susceptibility to EBOV and MARV, respectively, whereas the other bat cell lines tested are similarly infected with both viruses. In FBKT1 and ZFBK13-76E, unique amino acid (aa) sequences are found in the Niemann-Pick C1 (NPC1) protein, one of the cellular receptors interacting with the filovirus glycoprotein (GP). These aa residues, as well as a few aa differences between EBOV and MARV GPs, are crucial for the differential susceptibility to filoviruses. Taken together, our findings indicate that the heterogeneity of bat NPC1 orthologs is an important factor controlling filovirus species-specific host tropism. |
Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article |
URI: | http://hdl.handle.net/2115/76927 |
Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc) 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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