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Influence of respiration on dose calculation in stereotactic body radiotherapy of the lung

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Title: Influence of respiration on dose calculation in stereotactic body radiotherapy of the lung
Authors: Yamazaki, Rie Browse this author
Onimaru, Rikiya Browse this author →KAKEN DB
Katoh, Norio Browse this author →KAKEN DB
Inoue, Tetsuya Browse this author →KAKEN DB
Nishioka, Tetsuya Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Date, Hiroyuki Browse this author →KAKEN DB
Keywords: Stereotactic body radiotherapy
Lung tumor
Dose calculation
Chest wall motion
Issue Date: Jul-2014
Publisher: Springer
Journal Title: Radiological physics and technology
Volume: 7
Issue: 2
Start Page: 284
End Page: 289
Publisher DOI: 10.1007/s12194-014-0263-4
PMID: 24643842
Abstract: Our purpose in this study was to evaluate the variation in calculated doses caused by respiration in stereotactic body radiotherapy (SBRT) of the lung. The study targeted ten patients who underwent SBRT for lung tumors. CT images were acquired during free breathing and in the inhalation and exhalation phases. We compared the CT image at inhalation with the image at exhalation so as to measure the change in lung volume, variation in the CT value, and displacement of the chest wall. The lung volume change was shown to be correlated with the maximum of the chest wall motion and with the variation in the CT value. A statistically significant difference was observed in the CT values between inhalation and exhalation (p < 0.05). The total dose variation at the isocenter was confined within ±2 %. However, the dose from individual beams can vary significantly when the chest wall moves more than 10 mm in natural breathing.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Radiological physics and technology. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊達 広行

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