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Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases : The Hokkaido Study on Environment and Children's Health

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Title: Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases : The Hokkaido Study on Environment and Children's Health
Other Titles: Maternal DEHP and childhood allergies and infectious diseases
Authors: Ait Bamai, Yu Browse this author
Miyashita, Chihiro Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Nakajima, Tamie Browse this author
Sasaki, Seiko Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: di(2-Ethylhexyl) phthalate
Infectious diseases
Immunoglobulin E
Prenatal exposure
Issue Date: 15-Mar-2018
Publisher: Elsevier
Journal Title: Science of the total environment
Volume: 618
Start Page: 1408
End Page: 1415
Publisher DOI: 10.1016/j.scitotenv.2017.09.270
Abstract: Phthalates are widely used in consumer products, and experimental studies suggest that exposure to phthalates increase the risk of allergies. However, epidemiologic evidence on the associations between prenatal phthalate exposure and allergies/infectious diseases and cord blood immunoglobulin E (IgE) levels is limited. This study aimed to evaluate the associations between maternal mono(2-ethylhexyl) phthalate (MEHP) levels and cord blood IgE levels at birth (n = 127), as well as the risk of allergies/infectious diseases in participants up to 7 years of age; the participants were 1.5 (n = 248), 3.5 (n = 222), 7 (n = 184) years of age. Maternal blood MEHP level in the second trimester was measured using gas chromatography-mass spectrometry. Participant characteristics were obtained from the medical birth records and self-administered questionnaires during pregnancy and after delivery. Wheeze and eczema were defined according to the Japanese version of the International Study of Asthma and Allergies in Childhood and the American Thoracic Society-Division of Lung Diseases questionnaire, respectively. Infectious diseases were defined using questionnaires for each specified age. To evaluate the associations between maternal MEHP and allergies or infectious diseases, we used logistic regression analysis and generalized estimating equations analysis. Maternal MEHP levels were negatively associated with cord blood IgE levels and increased risks of allergies and infectious diseases up to 7 years of age. This is the first study to investigate the effects of prenatal MEHP exposure on IgE levels at birth and allergies/infectious diseases up to 7 years of age. Further epidemiological studies should focus on other phthalate metabolites and their health effects on larger populations.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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