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Effects of Atrial Fibrillation on Long-Term Outcomes in Patients Hospitalized for Heart Failure in Japan

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Title: Effects of Atrial Fibrillation on Long-Term Outcomes in Patients Hospitalized for Heart Failure in Japan
Authors: Hamaguchi, Sanae Browse this author
Yokoshiki, Hisashi Browse this author →KAKEN DB
Kinugawa, Shintaro Browse this author →KAKEN DB
Tsuchihashi-Makaya, Miyuki Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Takeshita, Akira Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
The JCARE-CARD Investigators Browse this author
Keywords: Atrial fibrillation
Heart failure
Issue Date: 2009
Publisher: The Japanese Circulation Society
Journal Title: Circulation Journal
Volume: 73
Issue: 11
Start Page: 2084
End Page: 2090
Publisher DOI: 10.1253/circj.CJ-09-0316
Abstract: Background: Atrial fibrillation (AF) is a common arrhythmia in patients with heart failure (HF), but its prognostic importance is controversial. The effect of AF on long-term outcomes, including mortality and rehospitalization, among unselected HF patients hospitalized with HF in routine clinical practice in Japan was assessed in the present study. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied the characteristics and treatment strategies of a broad sample of patients hospitalized with worsening HF and the outcomes were followed with an average of 2.4 years of follow-up. The study cohort (n=2,659) was grouped according to the presence (n=937; 35.2%) or absence (n=1,722; 64.8%) of AF at baseline. After multivariable adjustment, patients with and without AF had a comparable risk for all-cause death (adjusted hazard ratio (HR) 0.931, 95% confidence interval (CI) 0.690-1.258, P=0.643), cardiac death (adjusted HR 0.949, 95%CI 0.655-1.377, P=0.784), rehospitalization because of the worsening HF (adjusted HR 1.028, 95%CI 0.816-1.295, P=0.816), and all-cause death or rehospitalization (adjusted HR 1.039, 95%CI 0.842-1.281, P=0.722). Conclusions: Among patients hospitalized for HF in Japan, AF was common, but was not an independent risk for long-term adverse outcomes, including death or rehospitalization, in routine clinical practice. (Circ J 2009; 73: 2084-2090)
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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