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Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction

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Title: Characteristics and Outcomes of Hospitalized Patients With Heart Failure and Reduced vs Preserved Ejection Fraction
Authors: Tsuchihashi-Makaya, Miyuki Browse this author
Hamaguchi, Sanae Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Yokota, Takashi Browse this author →KAKEN DB
Goto, Daisuke Browse this author
Yokoshiki, Hisashi Browse this author →KAKEN DB
Kato, Norihiro Browse this author
Takeshita, Akira Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
for the JCARE-CARD Investigators Browse this author
Keywords: Ejection fraction
Heart failure
Issue Date: 2009
Journal Title: Circulation Journal
Volume: 73
Issue: 10
Start Page: 1893
End Page: 1900
Publisher DOI: 10.1253/circj.CJ-09-0254
Abstract: Background: Heart failure (HF) with preserved ejection fraction (EF) is common. We compared the characteristics, treatments, and outcomes in HF patients with reduced vs preserved EF by using the national registry database in Japan. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) is a prospective observational study in a broad sample of patients hospitalized with worsening HF. The study enrolled 2,675 patients from 164 hospitals with an average of 2.4 years of follow-up. Patients with preserved EF (EF ?50% by echocardiography; n=429) were more likely to be older, female, have hypertension and atrial fibrillation, and less likely to have ischemic etiology compared with those with reduced EF (EF <40%; n=985). Unadjusted risk of in-hospital mortality (6.5% vs 3.9%; P=0.03) and post-discharge mortality (22.7% vs 17.8%; P=0.058) was slightly higher in patients with preserved EF, which, however, were not different after multivariable adjustment. Patients with preserved EF had similar rehospitalization rates (36.2% vs 33.4%; P=0.515) compared with patients with reduced EF. Conclusions: HF patients with preserved EF had a similar mortality risk and equally high rates of rehospitalization as those with reduced EF. Effective management strategies are critically needed to be established for this type of HF. (Circ J 2009; 73: 1893-1900)
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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