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Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan

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Title: Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan
Authors: Hamaguchi, Sanae Browse this author
Tsuchihashi-Makaya, Miyuki Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Yokota, Takashi Browse this author →KAKEN DB
Takeshita, Akira Browse this author
Yokoshiki, Hisashi Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
The JCARE-CARD Investigators Browse this author
Keywords: Anemia
Heart failure
Hemoglobin
Mortality
Prognosis
Issue Date: 2009
Publisher: The Japanese Circulation Society
Journal Title: Circulation Journal
Volume: 73
Issue: 10
Start Page: 1901
End Page: 1908
Publisher DOI: 10.1253/circj.CJ-09-0184
Abstract: Background: Anemia is common in patients with heart failure (HF) and is associated with worse outcomes. However, the effects of anemia are unknown in an unselected group of HF patients encountered in routine clinical practice in Japan. The impact of anemia on long-term outcomes including mortality and rehospitalization among patients hospitalized with HF was thus assessed. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied the characteristics and treatments in a broad sample of patients hospitalized with worsening HF and the outcomes were followed. Study cohorts (n=1,960) were classified into 4 groups by discharge hemoglobin quartiles: <10.1 g/dl (n=482), 10.1-11.9 g/dl (n=479), 12.0-13.6 g/dl (n=487), and ?13.7 g/dl (n=512). Of the total cohort of HF patients, 57% had anemia, defined by using the World Health Organization definition. Patients with lower hemoglobin quartiles had higher rates of all-cause death, cardiac death, and rehospitalization due to worsening HF. After multivariable adjustment, the risk for all-cause death, cardiac death, and rehospitalization significantly increased with low hemoglobin concentrations. Conclusions: Anemia was quite common especially in patients with HF encountered in routine clinical practice in Japan, and lower hemoglobin was independently associated with long-term adverse outcomes in these patients. (Circ J 2009; 73: 1901-1908)
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/76967
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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