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Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan
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| Title: | Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan |
| Authors: | Hamaguchi, Sanae Browse this author | | Tsuchihashi-Makaya, Miyuki Browse this author | | Kinugawa, Shintaro Browse this author →KAKEN DB | | Yokota, Takashi Browse this author →KAKEN DB | | Takeshita, Akira Browse this author | | Yokoshiki, Hisashi Browse this author →KAKEN DB | | Tsutsui, Hiroyuki Browse this author →KAKEN DB | | The JCARE-CARD Investigators Browse this author |
| Keywords: | Anemia | | Heart failure | | Hemoglobin | | Mortality | | Prognosis |
| Issue Date: | 2009 |
| Publisher: | The Japanese Circulation Society |
| Journal Title: | Circulation Journal |
| Volume: | 73 |
| Issue: | 10 |
| Start Page: | 1901 |
| End Page: | 1908 |
| Publisher DOI: | 10.1253/circj.CJ-09-0184 |
| Abstract: | Background: Anemia is common in patients with heart failure (HF) and is associated with worse outcomes. However, the effects of anemia are unknown in an unselected group of HF patients encountered in routine clinical practice in Japan. The impact of anemia on long-term outcomes including mortality and rehospitalization among patients hospitalized with HF was thus assessed. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied the characteristics and treatments in a broad sample of patients hospitalized with worsening HF and the outcomes were followed. Study cohorts (n=1,960) were classified into 4 groups by discharge hemoglobin quartiles: <10.1 g/dl (n=482), 10.1-11.9 g/dl (n=479), 12.0-13.6 g/dl (n=487), and ?13.7 g/dl (n=512). Of the total cohort of HF patients, 57% had anemia, defined by using the World Health Organization definition. Patients with lower hemoglobin quartiles had higher rates of all-cause death, cardiac death, and rehospitalization due to worsening HF. After multivariable adjustment, the risk for all-cause death, cardiac death, and rehospitalization significantly increased with low hemoglobin concentrations. Conclusions: Anemia was quite common especially in patients with HF encountered in routine clinical practice in Japan, and lower hemoglobin was independently associated with long-term adverse outcomes in these patients. (Circ J 2009; 73: 1901-1908) |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76967 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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