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Chronic Kidney Disease as an Independent Risk for Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan
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| Title: | Chronic Kidney Disease as an Independent Risk for Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan |
| Authors: | Hamaguchi, Sanae Browse this author | | Tsuchihashi-Makaya, Miyuki Browse this author | | Kinugawa, Shintaro Browse this author →KAKEN DB | | Yokota, Takashi Browse this author →KAKEN DB | | Ide, Tomomi Browse this author →KAKEN DB | | Takeshita, Akira Browse this author | | Tsutsui, Hiroyuki Browse this author →KAKEN DB | | The JCARE-CARD Investigators Browse this author |
| Keywords: | Heart failure | | Kidney | | Prognosis | | Survival |
| Issue Date: | 2009 |
| Publisher: | The Japanese Circulation Society |
| Journal Title: | Circulation Journal |
| Volume: | 73 |
| Issue: | 8 |
| Start Page: | 1442 |
| End Page: | 1447 |
| Publisher DOI: | 10.1253/circj.CJ-09-0062 |
| Abstract: | Background: Previous studies have demonstrated that renal dysfunction is common in patients with heart failure (HF), but it is not known whether chronic kidney disease (CKD) is associated with increased risks of long-term adverse outcomes in unselected HF patients encountered in current routine clinical practice in Japan. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied a broad sample of patients hospitalized with worsening HF and their outcomes with an average of 2.4 years of follow-up. The study cohort (n=2,013) were classified into 3 groups by estimated glomerular filtration rate (eGFR): ≥60 (n=579), 30-59 (n=1,025), and <30 ml · min-1 · 1.73 m-2 or patients with dialysis (n=409); 1,372 patients (70.3%) had an eGFR <60 ml · min-1 · 1.73 m-2 and 62 patients were treated with dialysis. The multivariable adjusted risk for all-cause death or rehospitalization increased with reduced eGFR; an adjusted hazard ratio (HR) 1.520 (95% confidence interval (CI) 1.186-1.949) for eGFR 30-59 ml · min-1 · 1.73 m-2 (P=0.001) and HR 2.566 (95%CI 1.885-3.492) for eGFR <30 ml · min-1 · 1.73 m-2 or patients with dialysis (P<0.001). Conclusions: CKD is common in HF and was independently associated with long-term adverse outcomes in a broad cohort of Japanese patients. (Circ J 2009; 73: 1442 - 1447) |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76968 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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