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Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival

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Title: Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival
Authors: Tsuchihashi-Makaya, Miyuki Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Yokoshiki, Hisashi Browse this author →KAKEN DB
Hamaguchi, Sanae Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Goto, Daisuke Browse this author
Goto, Kazutomo Browse this author
Takeshita, Akira Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
The JCARE-CARD Investigators Browse this author
Keywords: β-blocker
Heart failure
Issue Date: 2010
Publisher: The Japanese Circulation Society
Journal Title: Circulation Journal
Volume: 74
Issue: 7
Start Page: 1364
End Page: 1371
Publisher DOI: 10.1253/circj.CJ-09-0993
Abstract: Background: Previous studies demonstrated thatβ-blocker use at the time of hospital discharge significantly increased postdischarge treatment rates, associated with an early (60- to 90-day) survival benefit in patients with heart failure (HF). However, it is unknown whether this therapeutic approach can also improve the long-term survival. We thus examined the long-term effects ofβ-blocker use at discharge on outcomes in patients hospitalized for HF and left ventricular systolic dysfunction (LVSD) (ejection fraction <40%). Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) enrolled HF patients hospitalized with worsening symptoms and they were followed during an average of 2.2 years. A total of 947 patients had LVSD, among whom 624 (66%) were eligible to receive aβ-blocker at discharge. After adjustment for covariate and propensity score, discharge use ofβ-blocker, when compared to noβ-blocker use, was associated with a significant reduced risk of all-cause mortality (hazard ratio (HR) 0.564, 95% confidence interval (CI) 0.358-0.889, P=0.014) and cardiac mortality (HR 0.489, 95%CI 0.279-0.859, P=0.013) after hospital discharge. Conclusions: Beta-blocker use at the time of discharge was associated with a long-term survival benefit in a diverse cohort of patients hospitalized with HF. (Circ J 2010; 74: 1364-1371)
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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