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Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival
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| Title: | Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival |
| Authors: | Tsuchihashi-Makaya, Miyuki Browse this author | | Kinugawa, Shintaro Browse this author →KAKEN DB | | Yokoshiki, Hisashi Browse this author →KAKEN DB | | Hamaguchi, Sanae Browse this author | | Yokota, Takashi Browse this author →KAKEN DB | | Goto, Daisuke Browse this author | | Goto, Kazutomo Browse this author | | Takeshita, Akira Browse this author | | Tsutsui, Hiroyuki Browse this author →KAKEN DB | | The JCARE-CARD Investigators Browse this author |
| Keywords: | β-blocker | | Heart failure | | Outcome | | Re-admission | | Surviva |
| Issue Date: | 2010 |
| Publisher: | The Japanese Circulation Society |
| Journal Title: | Circulation Journal |
| Volume: | 74 |
| Issue: | 7 |
| Start Page: | 1364 |
| End Page: | 1371 |
| Publisher DOI: | 10.1253/circj.CJ-09-0993 |
| Abstract: | Background: Previous studies demonstrated thatβ-blocker use at the time of hospital discharge significantly increased postdischarge treatment rates, associated with an early (60- to 90-day) survival benefit in patients with heart failure (HF). However, it is unknown whether this therapeutic approach can also improve the long-term survival. We thus examined the long-term effects ofβ-blocker use at discharge on outcomes in patients hospitalized for HF and left ventricular systolic dysfunction (LVSD) (ejection fraction <40%). Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) enrolled HF patients hospitalized with worsening symptoms and they were followed during an average of 2.2 years. A total of 947 patients had LVSD, among whom 624 (66%) were eligible to receive aβ-blocker at discharge. After adjustment for covariate and propensity score, discharge use ofβ-blocker, when compared to noβ-blocker use, was associated with a significant reduced risk of all-cause mortality (hazard ratio (HR) 0.564, 95% confidence interval (CI) 0.358-0.889, P=0.014) and cardiac mortality (HR 0.489, 95%CI 0.279-0.859, P=0.013) after hospital discharge. Conclusions: Beta-blocker use at the time of discharge was associated with a long-term survival benefit in a diverse cohort of patients hospitalized with HF. (Circ J 2010; 74: 1364-1371) |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/76969 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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