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Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure

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Title: Predictors of Long-Term Adverse Outcomes in Elderly Patients Over 80 Years Hospitalized With Heart Failure
Authors: Hamaguchi, Sanae Browse this author
Kinugawa, Shintaro Browse this author →KAKEN DB
Goto, Daisuke Browse this author
Tsuchihashi-Makaya, Miyuki Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Yamada, Satoshi Browse this author
Yokoshiki, Hisashi Browse this author →KAKEN DB
Takeshita, Akira Browse this author
Tsutsui, Hiroyuki Browse this author →KAKEN DB
JCARE-CARD Investigators Browse this author
Keywords: Elderly
Heart failure
Issue Date: 2011
Publisher: The Japanese Circulation Society
Journal Title: Circulation Journal
Volume: 75
Issue: 10
Start Page: 2403
End Page: 2410
Publisher DOI: 10.1253/circj.CJ-11-0267
Abstract: Background: Aging is associated with adverse outcomes in patients with cardiac diseases. Whether elderly patients hospitalized with heart failure (HF) had increased risks for mortality and rehospitalization compared with younger patients during the long-term follow-up was examined. The predictors of these adverse outcomes were also identified. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) studied prospectively the characteristics and treatments in a broad sample of 2,675 patients hospitalized with worsening HF and the outcomes were followed up. The majority of elderly patients were female, had lower body mass index (BMI), a higher rate of ischemic, valvular, and hypertensive heart disease as etiologies of HF, a lower estimated glomerular filtration rate (eGFR), lower hemoglobin, and higher left ventricular ejection fraction values. Even after adjustment for covariates, the elderly patients were associated with higher risks of adverse outcomes. The predictors for all-cause death were: lower eGFR, lower BMI, male sex, sustained ventricular tachycardia or fibrillation (VT/VF), and the use of diuretics at discharge. Conclusions: Among patients hospitalized with HF, elderly patients had a worse prognosis than younger patients. Lower eGFR, lower BMI, male sex, sustained VT/VF, and diuretic use were independent predictors for all-cause death in these patients with higher risk. (Circ J 2011; 75: 2403-2410)
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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