| Title: | Left ventricular outflow tract velocity time integral in hospitalized heart failure with preserved ejection fraction |
| Authors: | Omote, Kazunori Browse this author |
| Nagai, Toshiyuki Browse this author →KAKEN DB |
| Iwano, Hiroyuki Browse this author →KAKEN DB |
| Tsujinaga, Shingo Browse this author →KAKEN DB |
| Kamiya, Kiwamu Browse this author →KAKEN DB |
| Aikawa, Tadao Browse this author →KAKEN DB |
| Konishi, Takao Browse this author |
| Sato, Takuma Browse this author |
| Kato, Yoshiya Browse this author |
| Komoriyama, Hirokazu Browse this author |
| Kobayashi, Yuta Browse this author |
| Yamamoto, Kazuhiro Browse this author |
| Yoshikawa, Tsutomu Browse this author |
| Saito, Yoshihiko Browse this author |
| Anzai, Toshihisa Browse this author →KAKEN DB |
| Keywords: | Heart failure with preserved ejection fraction |
| Left ventricular outflow tract velocity time integral |
| Prognosis risk stratification |
| Issue Date: | Feb-2020 |
| Publisher: | Wiley Periodicals, Inc |
| Journal Title: | ESC heart failure |
| Volume: | 7 |
| Issue: | 1 |
| Start Page: | 167 |
| End Page: | 175 |
| Publisher DOI: | 10.1002/ehf2.12541 |
| Abstract: | Aims The prognostic implication of left ventricular outflow tract velocity time integral (LVOT-VTI) on admission in hospitalized heart failure with preserved ejection fraction (HFpEF) patients has not been determined. We sought to investigate whether LVOT-VTI on admission is associated with worse clinical outcomes in hospitalized patients with HFpEF. Methods and results We studied consecutive 214 hospitalized HFpEF patients who had accessible LVOT-VTI data on admission, from a prospective HFpEF-specific multicentre registry. The primary outcome of interest was the composite of all-cause death and readmission due to heart failure. During a median follow-up period of 688 (interquartile range 162-810) days, the primary outcome occurred in 83 patients (39%). The optimal cut-off value of LVOT-VTI for the primary outcome estimated by receiver operating characteristic analysis was 15.8 cm. Lower LVOT-VTI was significantly associated with the primary outcome compared with higher LVOT-VTI (P = 0.005). Multivariable Cox regression analyses revealed that lower LVOT-VTI was an independent determinant of the primary outcome (hazard ratio 0.94, 95% confidence interval 0.91-0.98). In multivariable linear regression, haemoglobin level was the strongest independent determinant of LVOT-VTI among clinical parameters (beta coefficient = -0.61, P = 0.007). Furthermore, patients with lower LVOT-VTI and anaemia had the worst clinical outcomes among the groups (P < 0.001). Conclusions Lower admission LVOT-VTI was an independent determinant of worse clinical outcomes in hospitalized HFpEF patients, indicating that LVOT-VTI on admission might be useful for categorizing a low-flow HFpEF phenotype and risk stratification in hospitalized HFpEF patients. |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/77044 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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