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Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/77805

Title: Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study
Authors: Kobayashi, Sumitaka Browse this author →KAKEN DB
Sata, Fumihiro Browse this author
Murata, Katsuyuki Browse this author →KAKEN DB
Saijo, Yasuaki Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Itoh, Sachiko Browse this author →KAKEN DB
Minatoya, Machiko Browse this author →KAKEN DB
Yamazaki, Keiko Browse this author →KAKEN DB
Ait Bamai, Yu Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Kawamoto, Toshihiro Browse this author
Saito, Hirohisa Browse this author
Yaegashi, Nobuo Browse this author
Hashimoto, Koichi Browse this author
Mori, Chisato Browse this author
Itoh, Shuichi Browse this author
Yamagata, Zentaro Browse this author
Inadera, Hidekuni Browse this author
Kamijima, Michihiro Browse this author
Nakayama, Takeo Browse this author
Iso, Hiroyasu Browse this author
Shima, Masayuki Browse this author
Hirooka, Yasuaki Browse this author
Suganuma, Narufumi Browse this author
Kusuhara, Koichi Browse this author
Katoh, Takahiko Browse this author
Keywords: birthweight
caffeine
pregnancy
preterm birth
small for gestational age
the Japan Environment and Children's Study
Issue Date: May-2019
Publisher: John Wiley & Sons
Journal Title: Paediatric and Perinatal Epidemiology
Volume: 33
Issue: 3
Start Page: 185
End Page: 194
Publisher DOI: 10.1111/ppe.12551
Abstract: Background: Few previous studies have investigated the association between prenatal caffeine intake and birth size (small-for-gestational-age (SGA), preterm birth, and birthweight Z-score) in Japan. Objectives: We examined the dose-dependency of this association (prenatal caffeine consumption and birth size) as part of the Japan Environment and Children’s Study. Methods: A prospective birth cohort included 94,876 fetuses in Japan. Participants were enrolled between January 2011 and March 2014. Adjusted multiple linear regression and Cox regression models were used to examine the association between prenatal caffeine levels and infant birth size. Results: The median estimated caffeine consumption during pregnancy was 125.5 mg/day, as determined by self-administered questionnaires. There were 7,252 SGA infants (7.6%) and 4,281 preterm birth infants (4.5%). Compared with infants of mothers whose caffeine consumption during pregnancy was in the lowest quartile (4.2 to <86.4 mg/day), infants of mothers whose caffeine consumption was in the highest quartile 4 (205.5 to 5,080.0 mg/day) were at an increased risk of SGA (relative risk [RR]: 1.18; 95% confidence interval [CI]: 1.10, 1.27), and at an increased risk of preterm birth at the 2nd trimester of gestation (RR: 1.94; 95% CI: 1.12, 3.37), with a 0.32-day reduction in gestational age (95% CI: -0.52, -0.12) and with a 0.07 reduction in birthweight Z-score observed (95% CI: -0.09, -0.05). Conclusions: Prenatal caffeine consumption was associated with birth size. However, as the association between prenatal caffeine consumption and birth size was likely 5 confounded by unpredicted potential factors, our confidence in the true causality of the association is moderate.
Rights: This is the peer reviewed version of the following article: Dose‐dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study: Paediatric and perinatal epidemiology: 33(3), 185-194, 2019, which has been published in final form at https://doi.org/10.1111/ppe.12551. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Type: article (author version)
URI: http://hdl.handle.net/2115/77805
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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