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Clinical Outcomes of Biliary Drainage during a Neoadjuvant Therapy for Pancreatic Cancer: Metal versus Plastic Stents

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Title: Clinical Outcomes of Biliary Drainage during a Neoadjuvant Therapy for Pancreatic Cancer: Metal versus Plastic Stents
Authors: Kuwatani, Masaki Browse this author →KAKEN DB
Nakamura, Toru Browse this author →KAKEN DB
Hayashi, Tsuyoshi Browse this author
Kimura, Yasutoshi Browse this author →KAKEN DB
Ono, Michihiro Browse this author →KAKEN DB
Motoya, Masayo Browse this author →KAKEN DB
Imai, Koji Browse this author
Yamakita, Keisuke Browse this author
Goto, Takuma Browse this author →KAKEN DB
Takahashi, Kuniyuki Browse this author
Maguchi, Hiroyuki Browse this author
Hirano, Satoshi Browse this author →KAKEN DB
Keywords: Pancreatic neoplasms
Chemotherapy
Chemoradiotherapy
Jaundice
Stent
Issue Date: Mar-2020
Publisher: Editorial Office of Gut and Liver
Journal Title: Gut and Liver
Volume: 14
Issue: 2
Start Page: 269
End Page: 273
Publisher DOI: 10.5009/gnl18573
Abstract: Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC/NACRT) can be performed in patients with pancreatic cancer to improve survival. We aimed to clarify the clinical outcomes of biliary drainage with a metal stent (MS) or a plastic stent (PS) during NAC/NACRT. Between October 2013 and April 2016, 96 patients with pancreatic cancer were registered for NAC/NACRT. Of these, 29 patients who underwent biliary drainage with MS or PS before NAC/NACRT and a subsequent pancreatoduodenectomy were retrospectively analyzed with regard to patient characteristics, preoperative recurrent biliary obstruction rate, NAC/NACRT delay or discontinuation rate, and operative characteristics. The median age of the patients was 67 years. NAC and NACRT were performed in 14 and 15 patients, respectively, and MS and PS were used in 17 and 12 patients, respectively. Recurrent biliary obstruction occurred in 6% and 83% of the patients in the MS and PS groups, respectively (p<0.001). NAC/NACRT delay was observed in 35% and 50% of the patients in the MS and PS groups, respectively (p=0.680). NAC/NACRT discontinuation was observed in 12% and 17% of the patients in the MS and PS groups, respectively (p=1.000). The operative time in the MS group tended to be longer than that in the PS group (625 minutes vs 497 minutes, p=0.051), and the operative blood loss volumes and postoperative adverse event rates were not different between the two groups. MS was better than PS from the viewpoint of preventing recurrent biliary obstruction, although MS was similar to PS with regards to perioperative outcomes.
Rights: http://creativecommons.org/licenses/by-nc/4.0
Type: article
URI: http://hdl.handle.net/2115/77822
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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