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The intercellular expression of type-XVII collagen, laminin-332, and integrin-beta 1 promote contact following during the collective invasion of a cancer cell population

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Title: The intercellular expression of type-XVII collagen, laminin-332, and integrin-beta 1 promote contact following during the collective invasion of a cancer cell population
Authors: Kumagai, Yuji Browse this author
Nio-Kobayashi, Junko Browse this author
Ishida-Ishihara, Sumire Browse this author
Tachibana, Hiromi Browse this author
Omori, Ryosuke Browse this author
Enomoto, Atsushi Browse this author
Ishihara, Seiichiro Browse this author
Haga, Hisashi Browse this author →KAKEN DB
Keywords: Collective invasion
Contact following
Integrin-beta 1
l.aminin-332
Type-XVII collagen
Issue Date: 5-Jul-2019
Publisher: Elsevier
Journal Title: Biochemical and biophysical research communications
Volume: 514
Issue: 4
Start Page: 1115
End Page: 1121
Publisher DOI: 10.1016/j.bbrc.2019.05.058
Abstract: Cancer cells can invade as a population in various cancer tissues. This phenomenon is called collective invasion, which is associated with the metastatic potential and prognosis of cancer patients. The collectiveness of cancer cells is necessary for collective invasion. However, the mechanism underlying the generation of collectiveness by cancer cells is not well known. In this study, the phenomenon of contact following, where neighboring cells move in the same direction via intercellular adhesion, was investigated. An experimental system was created to observe the two-dimensional invasion using a collagen gel overlay to study contact following in collective invasion. The role of integrin-beta 1, one of the major extracellular matrix (ECM) receptors, in contact following was examined through the experimental system. Integrin-beta 1 was localized to the intercellular site in squamous carcinoma cells. Moreover, the intercellular adhesion and contact following were suppressed by treatment of an integrin-beta 1 inhibitory antibody. ECM proteins such as laminin-332 and type-XVII collagen were also localized to the intercellular site and critical for contact following. Collectively, it was demonstrated that the activity of integrin-beta 1 and expression of ECM proteins in the intercellular site promote contact following in the collective invasion of a cancer cell population. (C) 2019 Elsevier Inc. All rights reserved.
Rights: © 2019 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/78009
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 芳賀 永

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