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Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids

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Title: Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids
Authors: Yamamura, Ryodai Browse this author
Nakamura, Koshi Browse this author →KAKEN DB
Kitada, Naoya Browse this author
Aizawa, Tomoyasu Browse this author →KAKEN DB
Shimizu, Yu Browse this author
Nakamura, Kiminori Browse this author →KAKEN DB
Ayabe, Tokiyoshi Browse this author →KAKEN DB
Kimura, Takashi Browse this author
Tamakoshi, Akiko Browse this author →KAKEN DB
Keywords: gut microbiota
fecal short-chain fatty acids
serum short-chain fatty acids
dietary intake
human
Issue Date: 2020
Publisher: BMFH Press
Journal Title: Bioscience of Microbiota,Food And Health
Volume: 39
Issue: 1
Start Page: 11
End Page: 17
Publisher DOI: 10.12938/bmfh.19-010
Abstract: In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22-51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut micro biota ecosystem and dynamics of SCFAs in the human body.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/78193
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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