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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids
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| Title: | Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
| Authors: | Yamamura, Ryodai Browse this author | | Nakamura, Koshi Browse this author →KAKEN DB | | Kitada, Naoya Browse this author | | Aizawa, Tomoyasu Browse this author →KAKEN DB | | Shimizu, Yu Browse this author | | Nakamura, Kiminori Browse this author →KAKEN DB | | Ayabe, Tokiyoshi Browse this author →KAKEN DB | | Kimura, Takashi Browse this author | | Tamakoshi, Akiko Browse this author →KAKEN DB |
| Keywords: | gut microbiota | | fecal short-chain fatty acids | | serum short-chain fatty acids | | dietary intake | | human |
| Issue Date: | 2020 |
| Publisher: | BMFH Press |
| Journal Title: | Bioscience of Microbiota,Food And Health |
| Volume: | 39 |
| Issue: | 1 |
| Start Page: | 11 |
| End Page: | 17 |
| Publisher DOI: | 10.12938/bmfh.19-010 |
| Abstract: | In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22-51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut micro biota ecosystem and dynamics of SCFAs in the human body. |
| Rights: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/78193 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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