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Usefulness of transabdominal ultrasonography for assessing ulcerative colitis : a prospective, multicenter study

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/78260

Title: Usefulness of transabdominal ultrasonography for assessing ulcerative colitis : a prospective, multicenter study
Authors: Kinoshita, Kenji Browse this author
Katsurada, Takehiko Browse this author →KAKEN DB
Nishida, Mutsumi Browse this author →KAKEN DB
Omotehara, Satomi Browse this author
Onishi, Reizo Browse this author
Mabe, Katsuhiro Browse this author
Onodera, Aki Browse this author
Sato, Mami Browse this author
Eto, Kazunori Browse this author
Suya, Mitsutoshi Browse this author
Maemoto, Atsuo Browse this author →KAKEN DB
Hasegawa, Toru Browse this author
Yamamoto, Junji Browse this author
Mitsumori, Daiki Browse this author
Yoshii, Shinji Browse this author
Ono, Kota Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Ulcerative colitis
Transabdominal ultrasonography
Colonoscopy
Issue Date: Jun-2019
Publisher: Springer
Journal Title: Journal of gastroenterology
Volume: 54
Issue: 6
Start Page: 521
End Page: 529
Publisher DOI: 10.1007/s00535-018-01534-w
PMID: 30519747
Abstract: BackgroundTransabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn's disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC.MethodsAltogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. All patients underwent US and CS within 2days at five facilities. We divided the colon into six segments and examined each segment and the rectum using US and CS. US severity was graded 1-4 regarding bowel wall thickness, stratification, and ulceration. CS severity was also graded 1-4 according to Matts' endoscopic classification. Concordance between US and CS grades for all colonic segments was analyzed using kappa statistics. US and CS findings were also compared with the clinical disease activity index (CAI) and histological grade using Spearman's correlation coefficient.ResultsThere was moderate concordance between US and CS grades in all colonic segments (weighted =0.55, p<0.001). Concordance was rated moderate for each colonic segment but only slight for the rectum. The US grade was significantly correlated with the CAI score (r=0.40, p<0.001) and histological grade (r=0.35, p<0.001).ConclusionsThis prospective multicenter study showed moderate concordance between US and CS for assessing the disease activity of UC. Hence, US may be used more generally for evaluating UC in daily clinical practice.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/78260
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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