| Title: | Usefulness of transabdominal ultrasonography for assessing ulcerative colitis : a prospective, multicenter study |
| Authors: | Kinoshita, Kenji Browse this author |
| Katsurada, Takehiko Browse this author →KAKEN DB |
| Nishida, Mutsumi Browse this author →KAKEN DB |
| Omotehara, Satomi Browse this author |
| Onishi, Reizo Browse this author |
| Mabe, Katsuhiro Browse this author |
| Onodera, Aki Browse this author |
| Sato, Mami Browse this author |
| Eto, Kazunori Browse this author |
| Suya, Mitsutoshi Browse this author |
| Maemoto, Atsuo Browse this author →KAKEN DB |
| Hasegawa, Toru Browse this author |
| Yamamoto, Junji Browse this author |
| Mitsumori, Daiki Browse this author |
| Yoshii, Shinji Browse this author |
| Ono, Kota Browse this author →KAKEN DB |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | Ulcerative colitis |
| Transabdominal ultrasonography |
| Colonoscopy |
| Issue Date: | Jun-2019 |
| Publisher: | Springer |
| Journal Title: | Journal of gastroenterology |
| Volume: | 54 |
| Issue: | 6 |
| Start Page: | 521 |
| End Page: | 529 |
| Publisher DOI: | 10.1007/s00535-018-01534-w |
| PMID: | 30519747 |
| Abstract: | BackgroundTransabdominal ultrasonography (US) has been reported to be a useful tool for evaluating ulcerative colitis (UC) although with less well-established data than for Crohn's disease. This prospective multicenter study aimed to establish the usefulness of US compared with colonoscopy (CS) for assessing disease extent and activity of UC.MethodsAltogether, 173 patients with UC were prospectively enrolled, among whom 156 were eligible for this study. All patients underwent US and CS within 2days at five facilities. We divided the colon into six segments and examined each segment and the rectum using US and CS. US severity was graded 1-4 regarding bowel wall thickness, stratification, and ulceration. CS severity was also graded 1-4 according to Matts' endoscopic classification. Concordance between US and CS grades for all colonic segments was analyzed using kappa statistics. US and CS findings were also compared with the clinical disease activity index (CAI) and histological grade using Spearman's correlation coefficient.ResultsThere was moderate concordance between US and CS grades in all colonic segments (weighted =0.55, p<0.001). Concordance was rated moderate for each colonic segment but only slight for the rectum. The US grade was significantly correlated with the CAI score (r=0.40, p<0.001) and histological grade (r=0.35, p<0.001).ConclusionsThis prospective multicenter study showed moderate concordance between US and CS for assessing the disease activity of UC. Hence, US may be used more generally for evaluating UC in daily clinical practice. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/78260 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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