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Hokkaido University Collection of Scholarly and Academic Papers >
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Bioactive compounds in plant materials for the prevention of diabetesand obesity
| Title: | Bioactive compounds in plant materials for the prevention of diabetesand obesity |
| Authors: | Kato, Eisuke Browse this author →KAKEN DB |
| Keywords: | Diabetes | | digestive enzyme | | glucose uptake | | lipolysis | | obesity |
| Issue Date: | 3-Jun-2019 |
| Publisher: | Taylor & Francis |
| Journal Title: | Bioscience, Biotechnology, and Biochemistry |
| Volume: | 83 |
| Issue: | 6 |
| Start Page: | 975 |
| End Page: | 985 |
| Publisher DOI: | 10.1080/09168451.2019.1580560 |
| PMID: | 30773997 |
| Abstract: | Plant materials have been widely studied for their preventive and therapeutic effects for type 2 diabetes mellitus (T2DM) and obesity. The effect of a plant material arises from its constituents, and the study of these bioactive compounds is important to achieve a deeper understanding of its effect at the molecular level. In particular, the study of the effects of such bioactive compounds on various biological processes, from digestion to cellular responses, is required to fully understand the overall effects of plant materials in these health contexts. In this review, I summarize the bioactive compounds we have recently studied in our research group that target digestive enzymes, dipeptidyl peptidase-4, myocyte glucose uptake, and lipid accumulation in adipocytes. Abbreviations: AC: adenylyl cyclase; AMPK: AMP-activated protein kinase; βAR: β-adrenergic receptor; CA: catecholamine; cAMP: cyclic adenosine monophosphate; cGMP: cyclic guanosine monophosphate; DPP-4: dipeptidyl peptidase-4; ERK: extracellular signal-regulated kinase; GC: guanylyl cyclase; GH: growth hormone; GLP-1: glucagon-like peptide-1; GLUT: glucose transporter; HSL: hormone-sensitive lipase; IR: insulin receptor; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; MEK: MAPK/ERK kinase; MG: maltase-glucoamylase; NP: natriuretic peptide; NPR: natriuretic peptide receptor; mTORC2: mechanistic target of rapamycin complex-2; PC: proanthocyanidin; PI3K: phosphoinositide 3-kinase; PKA: cAMP-dependent protein kinase; PKB (AKT): protein kinase B; PKG: cGMP-dependent protein kinase; PPARγ: peroxisome proliferator-activated receptor-γ; SGLT1: sodium-dependent glucose transporter 1; SI: sucrase-isomaltase; T2DM: type 2 diabetes mellitus; TNFα: tumor necrosis factor-α. |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience, Biotechnology, and Biochemistry on 03/06/2019, available online: http://www.tandfonline.com/10.1080/09168451.2019.1580560. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/78403 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 加藤 英介
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