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The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers

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Title: The Expression, Functions and Mechanisms of Circular RNAs in Gynecological Cancers
Authors: Dong, Peixin Browse this author →KAKEN DB
Xu, Daozhi Browse this author
Xiong, Ying Browse this author
Yue, Junming Browse this author
Ihira, Kei Browse this author →KAKEN DB
Konno, Yosuke Browse this author →KAKEN DB
Watari, Hidemichi Browse this author →KAKEN DB
Issue Date: Jun-2020
Publisher: MDPI
Journal Title: Cancers
Volume: 12
Issue: 6
Start Page: 1472
Publisher DOI: 10.3390/cancers12061472
Abstract: Circular RNAs (circRNAs) are covalently closed, endogenous non-coding RNAs and certain circRNAs are linked to human tumors. Owing to their circular form, circRNAs are protected from degradation by exonucleases, and therefore, they are more stable than linear RNAs. Many circRNAs have been shown to sponge microRNAs, interact with RNA-binding proteins, regulate gene transcription, and be translated into proteins. Mounting evidence suggests that circRNAs are dysregulated in cancer tissues and can mediate various signaling pathways, thus affecting tumorigenesis, metastasis, and remodeling of the tumor microenvironment. First, we review the characteristics, biogenesis, and biological functions of circRNAs, and describe various mechanistic models of circRNAs. Then, we provide a systematic overview of the functional roles of circRNAs in gynecological cancers. Finally, we describe the potential future applications of circRNAs as biomarkers for prognostic stratification and as therapeutic targets in gynecological cancers. Although the function of most circRNAs remains elusive, some individual circRNAs have biologically relevant functions in cervical cancer, ovarian cancer, and endometrial cancer. Certain circRNAs have the potential to serve as biomarkers and therapeutic targets in gynecological cancers.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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