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Anti-obesity effects of chondroitin sulfate oligosaccharides from the skate Raja pulchra
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| Title: | Anti-obesity effects of chondroitin sulfate oligosaccharides from the skate Raja pulchra |
| Authors: | Li, Wen Browse this author | | Kobayashi, Taishi Browse this author | | Moroi, Syoichi Browse this author | | Kotake, Hiroki Browse this author | | Ikoma, Tomokazu Browse this author | | Saeki, Hiroki Browse this author →KAKEN DB | | Ura, Kazuhiro Browse this author →KAKEN DB | | Takagi, Yasuaki Browse this author →KAKEN DB |
| Keywords: | Skate | | Processing waste | | Chondroitin sulfate | | Lipase | | Adipocyte | | High-fat diet mice model |
| Issue Date: | 15-Jun-2019 |
| Publisher: | Elsevier |
| Journal Title: | Carbohydrate Polymers |
| Volume: | 214 |
| Start Page: | 303 |
| End Page: | 310 |
| Publisher DOI: | 10.1016/j.carbpol.2019.03.025 |
| Abstract: | We aimed to investigate the anti-obesity effects of chondroitin sulfate (CS) oligosaccharides obtained from cartilage of the skate Raja pulchra and to compare them with those of CSs of other molecular weights (MWts) (skate CS polysaccharides) and origins (shark CS, bovine CS). CSs suppressed pancreatic lipase activity as well as proliferation and lipid accumulation in mature adipocytes. Higher MWt CS had a greater lipase inhibitory activity than lower MWt CS. CSs of different origin show differing potencies for lipase inhibition and effects on adipocytes. Also, dietary intake of skate CS oligosaccharides could ameliorate obesity in high-fat diet mice model: it prevented gaining in body weight, liver weight and adipose tissue weight, maintained lower food consumption, inhibited intestinal absorption of triglyceride, and adjusted the serum endotoxin level. In conclusion, skate CS oligosaccharides have an anti-obesity activity, and the MWt and origin of the CSs may affect this activity. |
| Rights: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/78551 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 都木 靖彰
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