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Volume 68 Number 2 >

Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.68.2.77

Title: Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis
Authors: Shinya, Goto Browse this author
Satoru, Konnai Browse this author →KAKEN DB
Yuki, Hirano Browse this author
Junko, Kohara Browse this author
Tomohiro, Okagawa Browse this author →KAKEN DB
Naoya, Maekawa Browse this author →KAKEN DB
Yamato, Sajiki Browse this author
Kei, Watari Browse this author
Erina, Minato Browse this author
Atsuhi, Kobayashi Browse this author
Satoshi, Gondaira Browse this author →KAKEN DB
Hidetoshi, Higuchi Browse this author →KAKEN DB
Masateru, Koiwa Browse this author →KAKEN DB
Motoshi, Tajima Browse this author →KAKEN DB
Eiji, Taguchi Browse this author
Masaru, Ishida Browse this author
Ryoko, Uemura Browse this author →KAKEN DB
Shinji, Yamada Browse this author
Mika, K. Kaneko Browse this author →KAKEN DB
Yukinari, Kato Browse this author →KAKEN DB
Keiichi, Yamamoto Browse this author
Mikihiro, Toda Browse this author
Yasuhiko, Suzuki Browse this author →KAKEN DB
Shiro, Murata Browse this author →KAKEN DB
Kazuhiko, Ohashi Browse this author →KAKEN DB
Keywords: Mycoplasma bovis
Immunotherapy
PD-L1
PGE2
COX-2 inhibitor
Issue Date: May-2020
Publisher: Faculty of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 68
Issue: 2
Start Page: 77
End Page: 90
Abstract: Mycoplasma bovis (M. bovis) is a highly contagious pathogen and M. bovis-associated diseases, particularly pneumonia, occur predominantly as herd enzootics, causing considerable economic losses because of calf mortality, weight loss in surviving calves. In our previous studies, the programmed death-1(PD-1)/ PD-ligand 1 (PD-L1) pathway and prostaglandin E2 (PGE2) were shown to be involved in the immunosuppression during chronic infectious diseases in cattle. In this study, the efficacy of dual blockade of the PD-1/PD-L1 pathway and PGE2 in M. bovis infection in vivo was investigated using anti-bovine PDL1 rat-bovine chimeric antibody, Boch4G12, and cyclooxygenase 2 (COX-2) inhibitor, meloxicam. The calves treated with Boch4G12 and meloxicam significantly enhanced M. bovis-specific IFN-γ response after the administration. On the other hand, IFN-γ response was not activated in the controls and cattle treated with meloxicam alone throughout the experimental period. Interestingly, bacterial loads in nasal discharge and bronchoalveolar lavage fluid among calves treated with Boch4G12 with or without meloxicam were significantly decreased. These results suggest that the combination of anti-PD-L1 antibody with a COX-2 inhibitor is a candidate for therapeutic applications in calves infected with M. bovis.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/78601
Appears in Collections:Japanese Journal of Veterinary Research > Volume 68 Number 2

Submitter: 獣医学部図書室

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