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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy
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| Title: | Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy |
| Authors: | Noriyuki, Nagata Browse this author | | Hiroshi, Ohta Browse this author | | Nozomu, Yokoyama Browse this author | | Teoh, Yong B. Browse this author | | Nisa, Khoirun Browse this author | | Sasaki, Noboru Browse this author | | Osuga, Tatsuyuki Browse this author | | Morishita, Keitaro Browse this author | | Takiguchi, Mitsuyoshi Browse this author →KAKEN DB |
| Keywords: | canine | | CCECAI | | chronic enteropathy | | CIBDAI | | clinical disease | | immunosuppressant | | intestinal lymphangiectasia | | ultralow-fat diet |
| Issue Date: | Mar-2020 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of Veterinary Internal Medicine |
| Volume: | 34 |
| Issue: | 2 |
| Start Page: | 659 |
| End Page: | 668 |
| Publisher DOI: | 10.1111/jvim.15720 |
| Abstract: | Background In dogs with protein-losing enteropathy (PLE), data on the clinical characteristics of food-responsive PLE (FR-PLE) remain scarce. Objective To determine the clinical characteristics of FR-PLE in dogs responsive to ultralow-fat diet (ULFD) management. Animals Thirty-three dogs diagnosed with PLE based on standard diagnostic criteria. Methods Retrospective review of medical records. Clinical findings were compared between dogs with FR-PLE (FR-PLE group) and those with immunosuppressant-responsive PLE (IR-PLE) or nonresponsive PLE (NR-PLE) (IR/NR-PLE group). The area under the curve (AUC) of a receiver operating characteristic curve was used to evaluate the ability of factors to differentiate the FR-PLE and IR/NR-PLE groups. Survival time was compared between the FR-PLE and IR/NR-PLE groups. Results Twenty-three dogs responded to ULFD management and were diagnosed with FR-PLE. The canine chronic enteropathy clinical activity index (CCECAI) was significantly lower in the FR-PLE group than in the IR/NR-PLE group (P < .001). The AUC of CCECAI for differentiating the FR-PLE group was 0.935 (95% confidence interval [CI], 0.845-1.000) with an optimal cutoff value of 8 (sensitivity, 0.826; specificity, 0.889). Survival times were significantly longer in the FR-PLE group (median, not reached) than in the IR/NR-PLE group (median, 432 days; P < .001). Conclusions and Clinical Importance Dogs that respond to ULFD management and are diagnosed with FR-PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR-PLE from IR-PLE or NR-PLE. |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/78602 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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