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Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

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Title: Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy
Authors: Noriyuki, Nagata Browse this author
Hiroshi, Ohta Browse this author
Nozomu, Yokoyama Browse this author
Teoh, Yong B. Browse this author
Nisa, Khoirun Browse this author
Sasaki, Noboru Browse this author
Osuga, Tatsuyuki Browse this author
Morishita, Keitaro Browse this author
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: canine
chronic enteropathy
clinical disease
intestinal lymphangiectasia
ultralow-fat diet
Issue Date: Mar-2020
Publisher: John Wiley & Sons
Journal Title: Journal of Veterinary Internal Medicine
Volume: 34
Issue: 2
Start Page: 659
End Page: 668
Publisher DOI: 10.1111/jvim.15720
Abstract: Background In dogs with protein-losing enteropathy (PLE), data on the clinical characteristics of food-responsive PLE (FR-PLE) remain scarce. Objective To determine the clinical characteristics of FR-PLE in dogs responsive to ultralow-fat diet (ULFD) management. Animals Thirty-three dogs diagnosed with PLE based on standard diagnostic criteria. Methods Retrospective review of medical records. Clinical findings were compared between dogs with FR-PLE (FR-PLE group) and those with immunosuppressant-responsive PLE (IR-PLE) or nonresponsive PLE (NR-PLE) (IR/NR-PLE group). The area under the curve (AUC) of a receiver operating characteristic curve was used to evaluate the ability of factors to differentiate the FR-PLE and IR/NR-PLE groups. Survival time was compared between the FR-PLE and IR/NR-PLE groups. Results Twenty-three dogs responded to ULFD management and were diagnosed with FR-PLE. The canine chronic enteropathy clinical activity index (CCECAI) was significantly lower in the FR-PLE group than in the IR/NR-PLE group (P < .001). The AUC of CCECAI for differentiating the FR-PLE group was 0.935 (95% confidence interval [CI], 0.845-1.000) with an optimal cutoff value of 8 (sensitivity, 0.826; specificity, 0.889). Survival times were significantly longer in the FR-PLE group (median, not reached) than in the IR/NR-PLE group (median, 432 days; P < .001). Conclusions and Clinical Importance Dogs that respond to ULFD management and are diagnosed with FR-PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR-PLE from IR-PLE or NR-PLE.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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