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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler
| Title: | Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler |
| Authors: | MIYAJI, Hirofumi Browse this author →KAKEN DB | | MAYUMI, Kayoko Browse this author | | MIYATA, Saori Browse this author | | NISHIDA, Erika Browse this author →KAKEN DB | | SHITOMI, Kanako Browse this author | | HAMAMOTO, Asako Browse this author | | TANAKA, Saori Browse this author →KAKEN DB | | AKASAKA, Tsukasa Browse this author →KAKEN DB |
| Keywords: | Enterococcus faecalis | | Inflammatory response | | Surface pre-reacted glass-ionomer (S-PRG) filler | | Rat subcutaneous tissue |
| Issue Date: | 30-Jan-2020 |
| Publisher: | The Japanese Society for Dental Materials and Devices |
| Journal Title: | Dental Materials Journal |
| Volume: | 39 |
| Issue: | 2 |
| Start Page: | 287 |
| End Page: | 294 |
| Publisher DOI: | 10.4012/dmj.2019-029 |
| PMID: | 31776316 |
| Abstract: | Surface pre-reacted glass-ionomer (S-PRG) filler releases several ions, such as fluoride, borate and strontium ions, to exert bioactive effects. We fabricated an endodontic root canal sealer containing S-PRG fillers (S-PRG sealer) and then evaluated the antibacterial and anti-inflammatory properties of S-PRG sealer compared with sealer containing conventional silica fillers (silica sealer). Antibacterial tests showed that S-PRG sealer significantly reduced the turbidity of Enterococcus faecalis compared with silica sealer. Implantation of S-PRG or silica sealer blocks in rat subcutaneous tissue showed that S-PRG sealer decreased the proinflammatory response compared with silica sealer at 10 days post-implantation. In addition, immunostaining revealed that infiltration of CD68- and peroxidase-positive cells around the S-PRG sealer was significantly lower than that in silica sealer. Therefore, it was suggested that S-PRG sealer exhibits antibacterial and anti-inflammatory effects. |
| Rights: | © 2020 The Japanese Society for Dental Materials and Devices |
| Type: | article |
| URI: | http://hdl.handle.net/2115/78688 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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