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Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/78688

Title: Comparative biological assessments of endodontic root canal sealer containing surface pre-reacted glass-ionomer (S-PRG) filler or silica filler
Authors: MIYAJI, Hirofumi Browse this author →KAKEN DB
MAYUMI, Kayoko Browse this author
MIYATA, Saori Browse this author
NISHIDA, Erika Browse this author →KAKEN DB
SHITOMI, Kanako Browse this author
HAMAMOTO, Asako Browse this author
TANAKA, Saori Browse this author →KAKEN DB
AKASAKA, Tsukasa Browse this author →KAKEN DB
Keywords: Enterococcus faecalis
Inflammatory response
Surface pre-reacted glass-ionomer (S-PRG) filler
Rat subcutaneous tissue
Issue Date: 30-Jan-2020
Publisher: The Japanese Society for Dental Materials and Devices
Journal Title: Dental Materials Journal
Volume: 39
Issue: 2
Start Page: 287
End Page: 294
Publisher DOI: 10.4012/dmj.2019-029
PMID: 31776316
Abstract: Surface pre-reacted glass-ionomer (S-PRG) filler releases several ions, such as fluoride, borate and strontium ions, to exert bioactive effects. We fabricated an endodontic root canal sealer containing S-PRG fillers (S-PRG sealer) and then evaluated the antibacterial and anti-inflammatory properties of S-PRG sealer compared with sealer containing conventional silica fillers (silica sealer). Antibacterial tests showed that S-PRG sealer significantly reduced the turbidity of Enterococcus faecalis compared with silica sealer. Implantation of S-PRG or silica sealer blocks in rat subcutaneous tissue showed that S-PRG sealer decreased the proinflammatory response compared with silica sealer at 10 days post-implantation. In addition, immunostaining revealed that infiltration of CD68- and peroxidase-positive cells around the S-PRG sealer was significantly lower than that in silica sealer. Therefore, it was suggested that S-PRG sealer exhibits antibacterial and anti-inflammatory effects.
Rights: © 2020 The Japanese Society for Dental Materials and Devices
Type: article
URI: http://hdl.handle.net/2115/78688
Appears in Collections:歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮治 裕史

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