|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Health Sciences / Faculty of Health Sciences >
Peer-reviewed Journal Articles, etc >
Extracts of bilberry (Vaccinium myrtillus L.) fruits improve liver steatosis and injury in mice by preventing lipid accumulation and cell death
| Title: | Extracts of bilberry (Vaccinium myrtillus L.) fruits improve liver steatosis and injury in mice by preventing lipid accumulation and cell death |
| Authors: | Haga, Sanae Browse this author →KAKEN DB | | YiMin Browse this author | | Yamaki, Hikari Browse this author | | Jin, Shigeki Browse this author →KAKEN DB | | Sogon, Tetsuya Browse this author | | Morita, Naoki Browse this author →KAKEN DB | | Ozaki, Michitaka Browse this author →KAKEN DB |
| Keywords: | Bilberry fruits | | fatty liver | | liver injury | | non-alcoholic steatohepatitis (NASH) | | Vaccinium myrtillus |
| Issue Date: | 27-Jun-2019 |
| Publisher: | Taylor & Francis |
| Journal Title: | Bioscience biotechnology and biochemistry |
| Volume: | 83 |
| Issue: | 11 |
| Start Page: | 2110 |
| End Page: | 2120 |
| Publisher DOI: | 10.1080/09168451.2019.1634514 |
| PMID: | 31244392 |
| Abstract: | Bilberry has been reported to have anti-oxidant and anti-inflammatory properties. We studied the effect of bilberry (Vaccinium myrtillus L.) fruits extracts (BEs) on the pathogenesis caused by lipid accumulation in fatty liver and non-alcoholic steatohepatitis (NASH). 5 mu g/ml of BEs was enough to suppress lipid accumulation in the fatty liver model of the mouse hepatic AML12 cells. BEs increased cell viability and anti-oxidant capacity, presumably by activating (phosphorylating) Akt/STAT3 and inducing MnSOD/catalase. BEs also significantly reduced Rubicon and induced p62/SQSTM1, possibly contributing to reduce cellular lipids (lipophagy). When the mice were fed supplemented with BEs (5% or 10%, w/w), hepatic steatosis, injury, and hypercholesterolemia/hyperglycemia were significantly improved. Furthermore, histological and cytokine studies indicated that BEs possibly suppress hepatic inflammation (hepatitis) and fibrosis. Therefore, BEs improved liver steatosis and injury, and potentially suppress fibrosis by suppressing inflammatory response, which therefore may prevent the progression of fatty liver to NASH. |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience, biotechnology, and biochemistry on 27 Jun 2019, available online: http://www.tandfonline.com/doi/abs/10.1080/09168451.2019.1634514. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/78723 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 尾崎 倫孝
|
