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Extracts of bilberry (Vaccinium myrtillus L.) fruits improve liver steatosis and injury in mice by preventing lipid accumulation and cell death

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Title: Extracts of bilberry (Vaccinium myrtillus L.) fruits improve liver steatosis and injury in mice by preventing lipid accumulation and cell death
Authors: Haga, Sanae Browse this author →KAKEN DB
YiMin Browse this author
Yamaki, Hikari Browse this author
Jin, Shigeki Browse this author →KAKEN DB
Sogon, Tetsuya Browse this author
Morita, Naoki Browse this author →KAKEN DB
Ozaki, Michitaka Browse this author →KAKEN DB
Keywords: Bilberry fruits
fatty liver
liver injury
non-alcoholic steatohepatitis (NASH)
Vaccinium myrtillus
Issue Date: 27-Jun-2019
Publisher: Taylor & Francis
Journal Title: Bioscience biotechnology and biochemistry
Volume: 83
Issue: 11
Start Page: 2110
End Page: 2120
Publisher DOI: 10.1080/09168451.2019.1634514
PMID: 31244392
Abstract: Bilberry has been reported to have anti-oxidant and anti-inflammatory properties. We studied the effect of bilberry (Vaccinium myrtillus L.) fruits extracts (BEs) on the pathogenesis caused by lipid accumulation in fatty liver and non-alcoholic steatohepatitis (NASH). 5 mu g/ml of BEs was enough to suppress lipid accumulation in the fatty liver model of the mouse hepatic AML12 cells. BEs increased cell viability and anti-oxidant capacity, presumably by activating (phosphorylating) Akt/STAT3 and inducing MnSOD/catalase. BEs also significantly reduced Rubicon and induced p62/SQSTM1, possibly contributing to reduce cellular lipids (lipophagy). When the mice were fed supplemented with BEs (5% or 10%, w/w), hepatic steatosis, injury, and hypercholesterolemia/hyperglycemia were significantly improved. Furthermore, histological and cytokine studies indicated that BEs possibly suppress hepatic inflammation (hepatitis) and fibrosis. Therefore, BEs improved liver steatosis and injury, and potentially suppress fibrosis by suppressing inflammatory response, which therefore may prevent the progression of fatty liver to NASH.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Bioscience, biotechnology, and biochemistry on 27 Jun 2019, available online:
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 尾崎 倫孝

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