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Effect of Pancreatic Mass Size on Clinical Outcomes of Endoscopic Ultrasound-Guided Fine-Needle Aspiration

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Title: Effect of Pancreatic Mass Size on Clinical Outcomes of Endoscopic Ultrasound-Guided Fine-Needle Aspiration
Authors: Sugiura, Ryo Browse this author
Kuwatani, Masaki Browse this author →KAKEN DB
Hirata, Koji Browse this author
Sano, Itsuki Browse this author
Kato, Shin Browse this author
Kawakubo, Kazumichi Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Endoscopic ultrasonography
Endoscopic ultrasonography fine-needle aspiration
Pancreatic tumor
Issue Date: Jul-2019
Publisher: Springer
Journal Title: Digestive diseases and sciences
Volume: 64
Issue: 7
Start Page: 2006
End Page: 2013
Publisher DOI: 10.1007/s10620-018-5435-3
PMID: 30604374
Abstract: BackgroundEndoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has high diagnostic accuracy for pancreatic diseases. However, the effect of mass size on diagnostic accuracy has yet to be determined, especially for small pancreatic lesions. We aimed to determine the effect of pancreatic mass size on the diagnostic yield of EUS-FNA.MethodsWe searched the database in Hokkaido University Hospital between May 2008 and December 2016 and identified solid pancreatic lesions examined by EUS-FNA. All lesions were stratified into five groups based on mass sizes: groups A (<10mm), B (10-20mm), C (20-30mm), D (30-40mm) and E (40mm). The sensitivity, specificity, diagnostic accuracy and adverse event rate were retrospectively evaluated.ResultsWe analyzed a total of 788 solid pancreatic lesions in 761 patients. The patients included 440 males (57.8%) with a mean age of 65.7years. The sensitivities in groups A (n=36), B (n=223), C (n=304), D (n=147) and E (n=78) were 89.3%, 95.0%, 97.4%, 98.5% and 98.7%, respectively, and they significantly increased as the mass size increased (P<0.01, chi-squared test for trend). The diagnostic accuracies were 91.7%, 96.4%, 97.7%, 98.6% and 98.7%, respectively, and they also significantly increased as the mass size increased (P=0.03). Multivariate analysis showed that pancreatic mass size was associated with diagnostic accuracy. The adverse event rates were not significantly different among the five groups.ConclusionsThe sensitivities and diagnostic accuracies of EUS-FNA for solid pancreatic lesions are higher for lesions 10mm in size, and they are strongly correlated with mass size.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Digestive Diseases and Sciences. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 桒谷 将城

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