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Composition of plasmalogens in serum lipoproteins from patients with non-alcoholic steatohepatitis and their susceptibility to oxidation

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Title: Composition of plasmalogens in serum lipoproteins from patients with non-alcoholic steatohepatitis and their susceptibility to oxidation
Authors: Ikuta, Akiko Browse this author
Sakurai, Toshihiro Browse this author
Nishimukai, Megumi Browse this author →KAKEN DB
Takahashi, Yuji Browse this author
Nagasaka, Atsushi Browse this author
Hui, Shu-Ping Browse this author →KAKEN DB
Hara, Hiroshi Browse this author →KAKEN DB
Chiba, Hitoshi Browse this author →KAKEN DB
Keywords: Plasmalogen
Non-alcoholic steatohepatitis
Issue Date: Jun-2019
Publisher: Elsevier
Journal Title: Clinica chimica acta
Volume: 493
Start Page: 1
End Page: 7
Publisher DOI: 10.1016/j.cca.2019.02.020
PMID: 30796899
Abstract: Background: Plasmalogens are ether phospholipids (PL) with an alkenyl group including vinyl ether bound at the sn-1 position and a polyunsaturated fatty acid bound at the sn-2 position, and are susceptible to oxidation. To date, there are no reports on the relationship between plasmalogen in serum lipoproteins and non-alceolic steatohepatitis (NASH), caused by multiple factors including oxidative stress. Here, we have investigateu the distribution of plasmalogens in serum lipoproteins isolated from NASH patients and healthy volunteers. Methods: Serum lipoproteins were separated by gel-filtration chromatography, and analyzed for ethanolamine and choline plasmalogens using liquid chromatography-mass spectrometry. Results: Both plasmalogen levels were higher in HDL than in VLDL or LDL. The plasmalogens/PL ratio was significantly lower in NASH than controls, for all lipoprotein fractions. Ethanolamine plasmalogens containing 20:4 and 22:6 at the sn-2 position and choline plasmalogens containing 16:0 at the sn-1 position were predominant in each group. In oxidation test using LDL from healthy serum, both types of plasmalogens were decreased during the early stages of oxidation. Conclusion: Plasmalogens could be a potential biomarker for evaluating the early stages of oxidation in NASH.
Rights: © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 櫻井 俊宏

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