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Composition of plasmalogens in serum lipoproteins from patients with non-alcoholic steatohepatitis and their susceptibility to oxidation
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| Title: | Composition of plasmalogens in serum lipoproteins from patients with non-alcoholic steatohepatitis and their susceptibility to oxidation |
| Authors: | Ikuta, Akiko Browse this author | | Sakurai, Toshihiro Browse this author | | Nishimukai, Megumi Browse this author →KAKEN DB | | Takahashi, Yuji Browse this author | | Nagasaka, Atsushi Browse this author | | Hui, Shu-Ping Browse this author →KAKEN DB | | Hara, Hiroshi Browse this author →KAKEN DB | | Chiba, Hitoshi Browse this author →KAKEN DB |
| Keywords: | Plasmalogen | | Lipoprotein | | Non-alcoholic steatohepatitis | | Oxidation |
| Issue Date: | Jun-2019 |
| Publisher: | Elsevier |
| Journal Title: | Clinica chimica acta |
| Volume: | 493 |
| Start Page: | 1 |
| End Page: | 7 |
| Publisher DOI: | 10.1016/j.cca.2019.02.020 |
| PMID: | 30796899 |
| Abstract: | Background: Plasmalogens are ether phospholipids (PL) with an alkenyl group including vinyl ether bound at the sn-1 position and a polyunsaturated fatty acid bound at the sn-2 position, and are susceptible to oxidation. To date, there are no reports on the relationship between plasmalogen in serum lipoproteins and non-alceolic steatohepatitis (NASH), caused by multiple factors including oxidative stress. Here, we have investigateu the distribution of plasmalogens in serum lipoproteins isolated from NASH patients and healthy volunteers. Methods: Serum lipoproteins were separated by gel-filtration chromatography, and analyzed for ethanolamine and choline plasmalogens using liquid chromatography-mass spectrometry. Results: Both plasmalogen levels were higher in HDL than in VLDL or LDL. The plasmalogens/PL ratio was significantly lower in NASH than controls, for all lipoprotein fractions. Ethanolamine plasmalogens containing 20:4 and 22:6 at the sn-2 position and choline plasmalogens containing 16:0 at the sn-1 position were predominant in each group. In oxidation test using LDL from healthy serum, both types of plasmalogens were decreased during the early stages of oxidation. Conclusion: Plasmalogens could be a potential biomarker for evaluating the early stages of oxidation in NASH. |
| Rights: | © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/78740 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 櫻井 俊宏
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