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Relationship between diabetic macular edema and choroidal layer thickness

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Title: Relationship between diabetic macular edema and choroidal layer thickness
Authors: Endo, Hiroaki Browse this author
Kase, Satoru Browse this author →KAKEN DB
Takahashi, Mitsuo Browse this author
Saito, Michiyuki Browse this author →KAKEN DB
Yokoi, Masahiko Browse this author →KAKEN DB
Sugawara, Chisato Browse this author
Katsuta, Satoshi Browse this author
Ishida, Susumu Browse this author →KAKEN DB
Kase, Manabu Browse this author
Issue Date: 7-Jan-2020
Publisher: PLOS
Journal Title: PLoS ONE
Volume: 15
Issue: 1
Start Page: e0226630
Publisher DOI: 10.1371/journal.pone.0226630
Abstract: Purpose To investigate the relationship between diabetic macular edema (DME) and the choroidal layer thickness in diabetic patients. Methods This is a retrospective observation study. Three hundred eighteen eyes of 159 diabetes mellitus (DM) patients and age-matched 100 eyes of 79 healthy controls were enrolled. DME was defined as over 300 mu m in the central retinal subfield of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector. The central choroidal thickness (CCT), as well as inner and outer layers were determined based on enhanced depth imaging (EDI)-OCT. Diabetic patients with/without systemic diabetic treatments (DT) at the start of this study was defined as DT+ and DT-, respectively. The number of eyes examined was 62 and 256 eyes in DME+and DME-groups, respectively. DM patients were further subdivided into 4 groups with/without DME and DT; DME+DT+(35 eyes), DME-DT+(159 eyes), DME+DT-(27 eyes), and DME-DT-group (97 eyes). Multiple comparisons on CCT layers including control and each DM group were statistically examined. Results The total CCT layer was 254 +/- 83, 283 +/- 88, and 251 +/- 70 mu m in the control, DME+, and DME-group, respectively. A total CCT layer in DME+was significantly thicker than the DME-group (P < 0.05). The outer CCT layer was 195 +/- 75, 222 +/- 83, and 193 +/- 63 mu m in the control, DME+, and DME-group, respectively. The outer CCT layer in DME+ was significantly thicker than the DME-group (P < 0.05). In the subdivided groups, the total CCT layers in the control, DME+DT+, DME-DT+, DME+DT-and DME-DT-groups were 254 +/- 83, 274 +/- 88, 247 +/- 66, 290 +/- 84 and 258 +/- 75 mu m, respectively. The outer CCT layers in each group were 195 +/- 75, 214 +/- 83, 189 +/- 58, 228 +/- 77, and 201 +/- 70 mu m, respectively. Total CCT and the outer layer in DME+DT-was significantly thicker than the DME-DT+group (each P < 0.05). In contrast, there was no significant difference in inner layer between the groups. Conclusions The total and outer CCT layers of diabetic eyes were significantly thickened in the DME +DT-as compared with the DME-DT+group, suggesting that CCT may be related to the pathology of DME.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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