| Title: | Liver steatosis and dyslipidemia after HCV eradication by direct acting antiviral agents are synergistic risks of atherosclerosis |
| Authors: | Kawagishi, Naoki Browse this author |
| Suda, Goki Browse this author →KAKEN DB |
| Nakamura, Akinobu Browse this author →KAKEN DB |
| Kimura, Megumi Browse this author |
| Maehara, Osamu Browse this author |
| Suzuki, Kazuharu Browse this author |
| Nakamura, Akihisa Browse this author |
| Ohara, Masatsugu Browse this author |
| Izumi, Takaaki Browse this author |
| Umemura, Machiko Browse this author |
| Nakai, Masato Browse this author |
| Sho, Takuya Browse this author |
| Natsuizaka, Mitsuteru Browse this author →KAKEN DB |
| Morikawa, Kenichi Browse this author |
| Ogawa, Koji Browse this author →KAKEN DB |
| Kudo, Yusuke Browse this author |
| Nishida, Mutsumi Browse this author →KAKEN DB |
| Miyoshi, Hideaki Browse this author →KAKEN DB |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Issue Date: | 2018 |
| Publisher: | The Public Library of Science (PLOS) |
| Journal Title: | PLOS ONE |
| Volume: | 13 |
| Issue: | 12 |
| Start Page: | e0209615 |
| Publisher DOI: | 10.1371/journal.pone.0209615 |
| Abstract: | Aim: We comprehensively analyzed how hepatitis C virus (HCV) eradication by interferon (IFN)-free direct-acting-antiviral-agents (DAAs) affects liver steatosis and atherogenic risk. Methods: Patients treated with IFN-free-DAAs who underwent transient elastography before and at 24-weeks post-treatment, including controlled attenuation parameter (CAP), and achieved sustained viral response (SVR) were enrolled. The association between changes in liver steatosis, lipid-metabolism, and genetic and clinical factors was analyzed. Results: A total of 117 patients were included. The mean CAP and low-density lipoprotein cholesterol (LDL-C) levels were significantly elevated at SVR24. However, baseline LDL-C and CAP values were significantly negatively correlated with changes in these values after HCV eradication, indicating that in patients with high baseline values, the values generally decreased after HCV eradication. Mean small-dense LDL-C (sdLDL-C), which has greater atherogenic potential, was significantly elevated only in patients with both dyslipidemia (LDL-C >140 mg/dL) and liver steatosis (CAP >248 dB/m) at SVR24. Those patients had significant higher baseline BMI, LDL-C, and total-cholesterol levels. Conclusions: Generally, successful HCV eradication by IFN-free-DAAs decreases CAP and LDL-C in patients with high baseline values. However, elevated LDL-C was accompanied with elevated sdLDL-C only in patients with liver steatosis and dyslipidemia at SVR24; therefore, those patients may require closer monitoring. |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/78822 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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