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Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/78864

Title: Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring
Authors: Yamasaki, Shojiro Browse this author
Tomihara, Tomomi Browse this author
Kimura, Goh Browse this author
Ueno, Yukako Browse this author
Ketema, Rahel Mesfin Browse this author
Sato, Shin Browse this author →KAKEN DB
Mukai, Yuuka Browse this author →KAKEN DB
Sikder, Tajuddin Browse this author
Kurasaki, Masaaki Browse this author →KAKEN DB
Hosokawa, Toshiyuki Browse this author →KAKEN DB
Saito, Takeshi Browse this author →KAKEN DB
Keywords: Resveratrol
maternal
adult offspring
cholesterol
Issue Date: 10-Jul-2019
Publisher: Taylor & Francis
Journal Title: International journal of food sciences and nutrition
Volume: 71
Issue: 2
Start Page: 226
End Page: 234
Publisher DOI: 10.1080/09637486.2019.1639638
PMID: 31290360
Abstract: Resveratrol (RSV) can protect against non-communicable diseases by improving cholesterol metabolism. However, it is unclear that effects of maternal RSV intake on health of adult offspring. In this study, we examined effects of maternal RSV intake during lactation on cholesterol metabolism in adult male rat offspring. Female Wistar rats were fed a control diet (CON) supplemented with or without RSV (20 mg/kg body weight/day) during their lactation period. Male offspring were weaned onto a standard diet and maintained on this diet for 36 weeks. As a result, plasma cholesterol level significantly decreased in RSV offspring compared to CON offspring. Furthermore, a decrease in hepatic 3-hydroxy-3-methylglutaryl-CoA reductase level and an increase in hepatic LDL-receptor level were observed in the RSV offspring. These results indicate that maternal RSV intake causes long-term decrease in plasma cholesterol level in the offspring through suppression of hepatic cholesterol biosynthesis and promotion of hepatic cholesterol uptake.
Rights: This is the Author’s Original Manuscript of an article published by Taylor & Francis in International journal of food sciences and nutrition on 10 Jul 2019, available online: http://www.tandfonline.com/10.1080/09637486.2019.1639638.
Type: article (author version)
URI: http://hdl.handle.net/2115/78864
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山﨑 尚二郎

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