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Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring
Title: | Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring |
Authors: | Yamasaki, Shojiro Browse this author | Tomihara, Tomomi Browse this author | Kimura, Goh Browse this author | Ueno, Yukako Browse this author | Ketema, Rahel Mesfin Browse this author | Sato, Shin Browse this author →KAKEN DB | Mukai, Yuuka Browse this author →KAKEN DB | Sikder, Tajuddin Browse this author | Kurasaki, Masaaki Browse this author →KAKEN DB | Hosokawa, Toshiyuki Browse this author →KAKEN DB | Saito, Takeshi Browse this author →KAKEN DB |
Keywords: | Resveratrol | maternal | adult offspring | cholesterol |
Issue Date: | 10-Jul-2019 |
Publisher: | Taylor & Francis |
Journal Title: | International journal of food sciences and nutrition |
Volume: | 71 |
Issue: | 2 |
Start Page: | 226 |
End Page: | 234 |
Publisher DOI: | 10.1080/09637486.2019.1639638 |
PMID: | 31290360 |
Abstract: | Resveratrol (RSV) can protect against non-communicable diseases by improving cholesterol metabolism. However, it is unclear that effects of maternal RSV intake on health of adult offspring. In this study, we examined effects of maternal RSV intake during lactation on cholesterol metabolism in adult male rat offspring. Female Wistar rats were fed a control diet (CON) supplemented with or without RSV (20 mg/kg body weight/day) during their lactation period. Male offspring were weaned onto a standard diet and maintained on this diet for 36 weeks. As a result, plasma cholesterol level significantly decreased in RSV offspring compared to CON offspring. Furthermore, a decrease in hepatic 3-hydroxy-3-methylglutaryl-CoA reductase level and an increase in hepatic LDL-receptor level were observed in the RSV offspring. These results indicate that maternal RSV intake causes long-term decrease in plasma cholesterol level in the offspring through suppression of hepatic cholesterol biosynthesis and promotion of hepatic cholesterol uptake. |
Rights: | This is the Author’s Original Manuscript of an article published by Taylor & Francis in International journal of food sciences and nutrition on 10 Jul 2019, available online: http://www.tandfonline.com/10.1080/09637486.2019.1639638. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/78864 |
Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 山﨑 尚二郎
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