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Clinical Trials of Stem Cell Treatment for Spinal Cord Injury

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Title: Clinical Trials of Stem Cell Treatment for Spinal Cord Injury
Authors: Yamazaki, Kazuyoshi Browse this author
Kawabori, Masahito Browse this author →KAKEN DB
Seki, Toshitaka Browse this author
Houkin, Kiyohiro Browse this author →KAKEN DB
Keywords: stem cell
spinal cord injury
regenerative medicine
Issue Date: 2020
Publisher: MDPI
Journal Title: International Journal of Molecular Sciences
Volume: 21
Issue: 11
Start Page: 3994
Publisher DOI: 10.3390/ijms21113994
Abstract: There are more than one million patients worldwide su ering paralysis caused by spinal cord injury (SCI). SCI causes severe socioeconomic problems not only to the patients and their caregivers but also to society; therefore, the development of innovative treatments is crucial. Many pharmacological therapies have been attempted in an e ort to reduce SCI-related damage; however, no single therapy that could dramatically improve the serious long-term sequelae of SCI has emerged. Stem cell transplantation therapy, which can ameliorate damage or regenerate neurological networks, has been proposed as a promising candidate for SCI treatment, and many basic and clinical experiments using stem cells for SCI treatment have been launched, with promising results. However, the cell transplantation methods, including cell type, dose, transplantation route, and transplantation timing, vary widely between trials, and there is no consensus regarding the most e ective treatment strategy. This study reviews the current knowledge on this issue, with a special focus on the clinical trials that have used stem cells for treating SCI, and highlights the problems that remain to be solved before the widespread clinical use of stem cells can be adopted.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 川堀 真人

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