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Correlation between serum proinsulin levels and fatty liver : The Dynamics of Lifestyle and Neighborhood Community on Health Study Health Study

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Title: Correlation between serum proinsulin levels and fatty liver : The Dynamics of Lifestyle and Neighborhood Community on Health Study Health Study
Authors: Miya, Aika Browse this author
Nakamura, Akinobu Browse this author →KAKEN DB
Miyoshi, Hideaki Browse this author →KAKEN DB
Ukawa, Shigekazu Browse this author →KAKEN DB
Nakamura, Koshi Browse this author →KAKEN DB
Nakagawa, Takafumi Browse this author
Terauchi, Yasuo Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: Fatty liver
Pancreatic beta-cell dysfunction
Proinsulin
Issue Date: Jul-2020
Publisher: John Wiley & Sons
Journal Title: Journal of diabetes investigation
Volume: 11
Issue: 4
Start Page: 964
End Page: 970
Publisher DOI: 10.1111/jdi.13221
Abstract: Aims/Introduction We explored the association between fatty liver and pancreatic beta-cell dysfunction in a general population. Materials and Methods This cross-sectional study included 489 (53.8% women) community-dwelling Japanese adults. The extent of fatty liver was estimated using the fatty liver index (FLI). After all participants were divided into three groups - low (FLI <30), moderate (30 <= FLI <60) or high (FLI >= 60) degree of fatty liver - serum proinsulin levels transformed into natural logarithms were compared among the three groups. To determine whether obesity modified the association of interest, the participants were stratified into two groups according to the median body mass index. Next, to determine whether hyperinsulinemia modified the association of interest, a similar stratified analysis was carried out using the median serum insulin level. Results Logarithm (proinsulin) was significantly higher in the high FLI group than in the moderate and low groups, and it was significantly higher in the moderate group than in the low group after adjustment for age and sex (P < 0.05). Logarithm (proinsulin) was significantly higher in the high FLI group than in the low FLI group, regardless of body mass index, after adjustment for age and sex. A similar pattern was observed regardless of serum insulin levels. Conclusions The degree of fatty liver was positively associated with proinsulin level, regardless of the presence of obesity or hyperinsulinemia, suggesting that fatty liver reflects pancreatic beta-cell dysfunction.
Rights: http://creativecommons.org/licenses/by-nc/4.0/
Type: article
URI: http://hdl.handle.net/2115/78956
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 三好 秀明

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