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Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-G(q/11) protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells

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Title: Extracellular Ca2+ promotes nitric oxide production via Ca2+-sensing receptor-G(q/11) protein-endothelial nitric oxide synthase signaling in human vascular endothelial cells
Authors: Horinouchi, Takahiro Browse this author →KAKEN DB
Mazaki, Yuichi Browse this author
Terada, Koji Browse this author →KAKEN DB
Miwa, Soichi Browse this author →KAKEN DB
Keywords: Ca2+-sensing receptor
Endothelial nitric oxide synthase
Extracellular Ca2+
Issue Date: Aug-2020
Publisher: Japanese Pharmacological Society
Journal Title: Journal of pharmacological sciences
Volume: 143
Issue: 4
Start Page: 315
End Page: 319
Publisher DOI: 10.1016/j.jphs.2019.06.009
Abstract: This study examined the possible involvement of Ca2+-sensing receptor (CaSR) in nitric oxide (NO) production in human vascular endothelial cells. Extracellular Ca2+ elevated the intracellular Ca2+ concentration, the endothelial NO synthase (eNOS) phosphorylation level, and NO release from the cells. These responses were inhibited by a CaSR antagonist and a G(q/11) protein inhibitor. Application of an endothelial cell suspension induced vasorelaxation in isolated rat thoracic aorta precontracted by phenylephrine. Adding an NO scavenger to the organ bath abolished this vasorelaxation response. These results suggest that extracellular Ca2+ promotes NO generation via CaSR- and G(q/11) protein-mediated eNOS activation. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
Rights: https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/78969
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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