|
Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >
Relationship Between Severity of Fibrinolysis Based on Rotational Thromboelastometry and Conventional Fibrinolysis Markers
This item is licensed under:Creative Commons Attribution-NonCommercial 4.0 International
| Title: | Relationship Between Severity of Fibrinolysis Based on Rotational Thromboelastometry and Conventional Fibrinolysis Markers |
| Authors: | Saito, Tomoyo Browse this author | | Hayakawa, Mineji Browse this author →KAKEN DB | | Honma, Yoshinori Browse this author | | Mizugaki, Asumi Browse this author →KAKEN DB | | Yoshida, Tomonao Browse this author →KAKEN DB | | Katabami, Kenichi Browse this author | | Wada, Takeshi Browse this author →KAKEN DB | | Maekawa, Kunihiko Browse this author |
| Keywords: | hyperfibrinolysis | | out-of-hospital cardiac arrest | | rotational thromboelastometry | | tissue plasminogen activator | | alpha(2)-plasmin inhibitor |
| Issue Date: | 15-Jun-2020 |
| Publisher: | SAGE Publications |
| Journal Title: | Clinical and applied thrombosis/hemostasis |
| Volume: | 26 |
| Start Page: | UNSP 1076029620933003 |
| Publisher DOI: | 10.1177/1076029620933003 |
| Abstract: | The association between severity of fibrinolysis, ascertained by rotational thromboelastometry to diagnose hyperfibrinolysis in patients with out-of-hospital cardiac arrest (OHCA), and conventional fibrinolysis markers (ie, tissue-plasminogen activator [t-PA], plasminogen, alpha(2)-plasmin inhibitor [alpha(2)-PI], and plasminogen activator inhibitor [PAI]) with key roles in the fibrinolytic system was investigated. This prospective observational study included 5 healthy volunteers and 35 patients with OHCA from the Hokkaido University Hospital. Blood samples were drawn immediately upon admission to the emergency department. Assessments of the extrinsic pathway using tissue factor activation (EXTEM) and of fibrinolysis by comparison with EXTEM after aprotinin addition (APTEM) were undertaken. Conventional coagulation and fibrinolysis markers were measured in the stored plasma samples. Significant hyperfibrinolysis observed in EXTEM disappeared in APTEM. Patients exhibited significantly higher levels of fibrinogen/fibrin degradation products, plasmin-alpha(2)-PI complex, and t-PA but lower levels of fibrinogen, plasminogen, and alpha(2)-PI than healthy controls. The PAI level was unchanged. Fibrinolytic parameters of EXTEM correlated with levels of lactate and conventional fibrinolysis markers, especially t-PA. Increased t-PA activity and decreased plasminogen and alpha(2)-PI significantly correlated with increased severity of fibrinolysis (hyperfibrinolysis). |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/78981 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
