HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Prognoses, outcomes, and clinicopathological characteristics of very elderly patients with hepatocellular carcinoma who underwent hepatectomy

This item is licensed under:Creative Commons Attribution 4.0 International

Files in This Item:

The file(s) associated with this item can be obtained from the following URL: https://doi.org/10.1186/s12957-020-01899-4


Title: Prognoses, outcomes, and clinicopathological characteristics of very elderly patients with hepatocellular carcinoma who underwent hepatectomy
Authors: Shimada, Shingo Browse this author →KAKEN DB
Kamiyama, Toshiya Browse this author →KAKEN DB
Orimo, Tatsuya Browse this author
Nagatsu, Akihisa Browse this author
Asahi, Yoh Browse this author
Sakamoto, Yuzuru Browse this author
Kamachi, Hirofumi Browse this author →KAKEN DB
Taketomi, Akinobu Browse this author →KAKEN DB
Keywords: Elderly
Hepatectomy
Hepatocellular carcinoma
Issue Date: 10-Jun-2020
Publisher: BioMed Central
Journal Title: World journal of surgical oncology
Volume: 18
Issue: 1
Start Page: 122
Publisher DOI: 10.1186/s12957-020-01899-4
Abstract: Objectives The aim was to evaluate the prognostic factors, clinicopathological characteristics, and surgical outcomes after hepatectomy in very elderly patients with hepatocellular carcinoma (HCC). Methods We analyzed 796 patients with HCC from 2000 to 2017. Patients aged 80 years or older were classified into the very elderly group (group VE;n= 49); patients younger than 80 years old and aged 65 years or older were classified into the elderly group (group E;n= 363), and patients younger than 65 years old were classified into the young group (group Y;n= 384). We investigated the prognoses, clinicopathological characteristics, and surgical outcomes after hepatectomy. Results The number of surgical procedures and outcomes, including morbidities, was not significantly different. Groups VE, E, and Y showed similar prognoses in terms of both survival and recurrence. In group VE, prothrombin activity (PA) < 80% and PIVKA-II >= 400 mAU/ml were unfavorable factors for survival, and PIVKA-II >= 400 mAU/ml and the presence of portal venous invasion (PVI), hepatic venous invasion, and fibrosis were unfavorable factors for recurrence. In group E, ChE < 180 IU/l, AFP >= 20 ng/ml, tumor size >= 10 cm, and the presence of multiple tumors, PVI, and hepatic venous invasion (HVI) were unfavorable factors for survival, and ChE < 180 IU/l, tumor size >= 10 cm, and the presence of multiple tumors, PVI, and HVI were unfavorable factors for recurrence. In group Y, AFP >= 20 ng/ml, the presence of multiple tumors, poor differentiation, PVI, HVI, and blood loss >= 400 ml were unfavorable factors for survival, and PA < 80%, albumin < 3.5 g/dl, AFP >= 20 ng/ml, tumor size >= 10 cm, and the presence of multiple tumors, poor differentiation, and PVI were unfavorable factors for recurrence. Conclusions Tumor factors might have limited influence on the prognosis of very elderly patients, and liver function reserve might be important for the long-term survival of very elderly patients. Hepatectomy can be performed safely, even in very elderly patients. Hepatectomy should not be avoided in very elderly patients with HCC if patients have a good general status because these patients have the same prognoses as nonelderly individuals.
Rights: http://creativecommons.org/licenses/by/4.0/
Type: article
URI: http://hdl.handle.net/2115/78983
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University