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Macrolide treatment for COVID-19 : Will this be the way forward?

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Title: Macrolide treatment for COVID-19 : Will this be the way forward?
Authors: Ohe, Masashi Browse this author
Shida, Haruki Browse this author
Jodo, Satoshi Browse this author
Kusunoki, Yoshihiro Browse this author
Seki, Masahide Browse this author
Furuya, Ken Browse this author
Goudarzi, Houman Browse this author →KAKEN DB
Keywords: COVID-19
SARS-CoV-2
macrolide
Issue Date: Apr-2020
Publisher: IRCA-BSSA
Journal Title: BioScience Trends
Volume: 14
Issue: 2
Start Page: 159
End Page: 160
Publisher DOI: 10.5582/bst.2020.03058
Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that has developed in late 2019 and 2020 is a serious threat to human health. With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. Using structure-based drug selection for identification of SARS-CoV-2 protease inhibitors, old drugs such as macrolides (MAC) were predicted to be effective for COVID-19. Lately, the anti-viral effects of macrolides have attracted considerable attention. Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. We believe that treatments with macrolides alone or in combination with other drugs are promising and open the possibility of an international strategy to fight this emerging viral infection.
Type: article
URI: http://hdl.handle.net/2115/78986
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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