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The Responsiveness of Triaxial Accelerometer Measurement of Gait Ataxia Is Higher than That of the Scale for the Assessment and Rating of Ataxia in the Early Stages of Spinocerebellar Degeneration

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Title: The Responsiveness of Triaxial Accelerometer Measurement of Gait Ataxia Is Higher than That of the Scale for the Assessment and Rating of Ataxia in the Early Stages of Spinocerebellar Degeneration
Authors: Shirai, Shinichi Browse this author
Yabe, Ichiro Browse this author →KAKEN DB
Takahashi-Iwata, Ikuko Browse this author
Matsushima, Masaaki Browse this author
Ito, Yoichi M. Browse this author
Takakusaki, Kaoru Browse this author →KAKEN DB
Sasaki, Hidenao Browse this author →KAKEN DB
Keywords: Cerebellar ataxia
Quantitative evaluation
Accelerometer
Biomarker
Issue Date: Aug-2019
Publisher: Springer
Journal Title: Cerebellum
Volume: 18
Issue: 4
Start Page: 721
End Page: 730
Publisher DOI: 10.1007/s12311-019-01025-5
PMID: 30993540
Abstract: We reported previously that the average medial-lateral gait amplitude while walking on a straight path determined using triaxial accelerometers fixed on the middle of the upper back may be a quantitative and concise indicator for the severity of cerebellar ataxia. Considering that gait ataxia is a typical initial symptom in a variety of spinocerebellar degeneration (SCD), we aimed to develop quantitative biomarkers for cerebellar ataxia as metric variables. We used triaxial accelerometers to analyze gait parameters in 14 patients with SCD at 3 points over 3 years (at baseline, 1.5 years and 3 years). Analysis of covariance (ANCOVA) models adjusted for the baseline scores were used to estimate sample sizes. The mean medial-lateral amplitude (ML) gained by a triaxial accelerometer fixed on upper back could detect the each 1.5-year change. In the 14 patients, the mean ML(m) was 0.032 +/- 0.007(SD) at entry, 0.037 +/- 0.008 after 1.5-year follow, and 0.042 +/- 0.020 after 3-year follow. In contrast, SARA gait scores were 2.9, 2.9, and 3.0, respectively. The responsiveness of the quantitative evaluation of gait ataxia by triaxial accelerometers is higher than that of the SARA within a 1.5-year follow-up period. Gait analysis by triaxial accelerometers will be complementary to the evaluation of scales like SARA in the assessment of clinical severity of SCD patients in early stage.
Rights: This is a post-peer-review, pre-copyedit version of an article published in The Cerebellum. The final authenticated version is available online at: https://doi.org/10.1007/s12311-019-01025-5
Type: article (author version)
URI: http://hdl.handle.net/2115/79017
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 矢部 一郎

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