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Serological evidence of Zika virus infection in non-human primates in Zambia
| Title: | Serological evidence of Zika virus infection in non-human primates in Zambia |
| Authors: | Wastika, Christida E. Browse this author | | Sasaki, Michihito Browse this author | | Yoshii, Kentaro Browse this author | | Anindita, Paulina D. Browse this author | | Hang'ombe, Bernard M. Browse this author | | Mweene, Aaron S. Browse this author | | Kobayashi, Shintaro Browse this author | | Kariwa, Hiroaki Browse this author | | Carr, Michael J. Browse this author | | Hall, William W. Browse this author | | Eshita, Yuki Browse this author | | Orba, Yasuko Browse this author →KAKEN DB | | Sawa, Hirofumi Browse this author →KAKEN DB |
| Keywords: | Zika virus |
| Issue Date: | Aug-2019 |
| Publisher: | Springer |
| Journal Title: | Archives of virology |
| Volume: | 164 |
| Issue: | 8 |
| Start Page: | 2165 |
| End Page: | 2170 |
| Publisher DOI: | 10.1007/s00705-019-04302-0 |
| Abstract: | Zika virus (ZIKV) circulation occurs between non-human primates (NHPs) in a sylvatic transmission cycle. To investigate evidence of flavivirus infection in NHPs in Zambia, we performed a plaque reduction neutralization test (PRNT) to quantify neutralizing antibodies. PRNT revealed that sera from NHPs (African green monkeys and baboons) exhibited neutralizing activity against ZIKV (34.4%; 33/96), whereas a PRNT for yellow fever virus using NHP sera showed no neutralization activity. ZIKV genomic RNA was not detected in splenic tissues from NHPs, suggesting that the presence of anti-ZIKV neutralizing antibodies represented resolved infections. Our evidence suggests that ZIKV is maintained in NHP reservoirs in Zambia. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79038 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 澤 洋文
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