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Serological evidence of Zika virus infection in non-human primates in Zambia

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/79038

Title: Serological evidence of Zika virus infection in non-human primates in Zambia
Authors: Wastika, Christida E. Browse this author
Sasaki, Michihito Browse this author
Yoshii, Kentaro Browse this author
Anindita, Paulina D. Browse this author
Hang'ombe, Bernard M. Browse this author
Mweene, Aaron S. Browse this author
Kobayashi, Shintaro Browse this author
Kariwa, Hiroaki Browse this author
Carr, Michael J. Browse this author
Hall, William W. Browse this author
Eshita, Yuki Browse this author
Orba, Yasuko Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Keywords: Zika virus
Issue Date: Aug-2019
Publisher: Springer
Journal Title: Archives of virology
Volume: 164
Issue: 8
Start Page: 2165
End Page: 2170
Publisher DOI: 10.1007/s00705-019-04302-0
Abstract: Zika virus (ZIKV) circulation occurs between non-human primates (NHPs) in a sylvatic transmission cycle. To investigate evidence of flavivirus infection in NHPs in Zambia, we performed a plaque reduction neutralization test (PRNT) to quantify neutralizing antibodies. PRNT revealed that sera from NHPs (African green monkeys and baboons) exhibited neutralizing activity against ZIKV (34.4%; 33/96), whereas a PRNT for yellow fever virus using NHP sera showed no neutralization activity. ZIKV genomic RNA was not detected in splenic tissues from NHPs, suggesting that the presence of anti-ZIKV neutralizing antibodies represented resolved infections. Our evidence suggests that ZIKV is maintained in NHP reservoirs in Zambia.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/79038
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 澤 洋文

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