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Discovery of Ti-Binding Abilities of Phosphorylated-Chitin and -Collagen

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/79053

Title: Discovery of Ti-Binding Abilities of Phosphorylated-Chitin and -Collagen
Authors: Kuboki, Yoshinori Browse this author →KAKEN DB
Tokura, Seiichi Browse this author →KAKEN DB
Yagami, Kimitoshi Browse this author
Furusawa, Toshitake Browse this author
Morimoto, Kouichi Browse this author
Song, Qin Browse this author
Iku, Souhei (Xiaobing) Browse this author
Kurasaki, Masaaki Browse this author →KAKEN DB
Keywords: Titanium (Ti)
Binding with Ti
Phosphorylation
Chitin
Collagen
Issue Date: 2020
Publisher: THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY
Journal Title: Journal of Hard Tissue Biology
Volume: 29
Issue: 1
Start Page: 45
End Page: 48
Publisher DOI: 10.2485/jhtb.29.45
Abstract: Previously we have discovered that titanium (Ti) binds with bone phosphoproteins SIBLING protein family, by using a Ti beads chromatography. Furthermore, we showed that the isolated bone phosphoproteins remarkably enhanced bone formation when we coated the Ti device with them and implanted into rat calvaria. Therefore, we have called the Ti-binding bone phosphoproteins as “the implant proteins.” This discovery encouraged us to create a new biomolecule that can simulate the functions of the implant proteins. Since significant characteristics of the implant proteins are the presence of multiple phosphate groups and the occurrence of single cell-adhering RGD sequence, we decided for the first place to phosphorylate chitin and collagen to see whether they acquire or increase Ti-binding ability. Results showed that more than 70% of phosphorylated chitin bound with Ti, and phosphorylated collagen enhanced about 7% of its Ti-binding ability. These modified biomolecules, P-chitin and P-collagen will become highly useful for new development of Ti-related bone regenerative medicine.
Type: article
URI: http://hdl.handle.net/2115/79053
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久保木 芳徳

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