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Investigation of energy absorption by clustered gold nanoparticles

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Title: Investigation of energy absorption by clustered gold nanoparticles
Authors: Kwon, Jihun Browse this author
Sutherland, Kenneth Browse this author →KAKEN DB
Makarova, Anastasia Browse this author
Matsuura, Taeko Browse this author →KAKEN DB
Hashimoto, Takayuki Browse this author →KAKEN DB
Peng, Hao Browse this author
Toshito, Toshiyuki Browse this author
Umegaki, Kikuo Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Shimizu, Shinichi Browse this author →KAKEN DB
Keywords: Gold nanoparticles
Dose enhancement
Radiation sensitizer
Monte Carlo simulation
Issue Date: 15-Aug-2018
Publisher: Elsevier
Journal Title: Nuclear instruments & methods in physics research section b-beam interactions with materials and atoms
Volume: 429
Start Page: 34
End Page: 41
Publisher DOI: 10.1016/j.nimb.2018.05.033
Abstract: The utilization of gold nanoparticles (GNPs) as a radiation sensitizer has received broad attention. Although GNPs form clusters in living cells, most previous simulation studies have assumed a homogeneous distribution of GNPs. In this study, a GNP cluster was constructed for simulations and the impact of cluster formation on dose enhancement was examined. Energy absorption by the GNPs was compared between clustered and homogeneous distributions for several different GNP concentrations and diameters under 100 keV X-ray irradiations. Our simulations showed that clusters more efficiently absorbed the secondary electrons and photons produced by GNPs themselves. Furthermore, the impact of cluster formation on dose enhancement was more significant for smaller GNPs and higher concentrations. Our results suggest that previous simulations assuming a homogeneous GNP distribution have overestimated the dose enhancement, especially for smaller GNPs and higher concentrations. These findings should guide the selection of GNP size and concentration for effectively optimizing dose enhancement in future studies.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 清水 伸一

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