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Therapeutic effects and adaptive limits of an acellular technique by ultrapuri fied alginate (UPAL) gel implantation in canine osteochondral defect models

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Title: Therapeutic effects and adaptive limits of an acellular technique by ultrapuri fied alginate (UPAL) gel implantation in canine osteochondral defect models
Authors: Onodera, Tomohiro Browse this author →KAKEN DB
Baba, Rikiya Browse this author →KAKEN DB
Kasahara, Yasuhiko Browse this author →KAKEN DB
Tsuda, Toshihiko Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Keywords: Cartilage
Alginate
Acellular technique
Animal model
Issue Date: Jun-2020
Publisher: Elsevier
Journal Title: Regenerative Therapy
Volume: 14
Start Page: 154
End Page: 159
Publisher DOI: 10.1016/j.reth.2020.01.001
Abstract: Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapuri fied alginate (UPAL) gel implantation in canine osteochondral defect models. Methods: Two osteochondral defects (diameters: 3.0 and 5.0 mm) were created on each patellar groove in both knees of 10 dogs. Defects were divided into four groups (n 1 / 4 10 each): Group 1, untreated 3.0-mm defect; Group 2, 3.0-mm defect with UPAL gel; Group 3, untreated 5.0-mm defect; and Group 4, 5.0-mm defect with UPAL gel. All surgical procedures were performed by individuals unfamiliar with the technique at an independent institution. Articular surfaces were evaluated grossly and histologically at 27 weeks after operation. Results: UPAL gel-treated osteochondral defects showed signi ficantly improved gross appearance in Group 4 and histological appearance in Groups 2 and 4. Reparative tissues in the 3.0-mm defect with UPAL gel were replaced by hyaline-like cartilage tissue. The 5.0-mm defects with UPAL gel were mostly covered with fibrocartilaginous tissue, whereas UPAL gel-untreated defects mostly remained uncovered by any tissue. Conclusions: Although an acellular technique using UPAL gel implantation signi ficantly enhanced osteochondral repair in canines, reparative tissues of the large defect with alginate gel comprised of fibrocartilaginous tissue. This surgical technique is effective, especially for small cartilage injuries. Further improvements are required before clinical application in cases of severe osteochondral defects in humans. (C) 2020, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/ 4.0/).
Rights: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/79073
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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