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Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/79147

Title: Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer
Authors: Kato, Fumi Browse this author →KAKEN DB
Kudo, Kohsuke Browse this author →KAKEN DB
Yamashita, Hiroko Browse this author →KAKEN DB
Baba, Motoi Browse this author
Shimizu, Ai Browse this author
Oyama-Manabe, Noriko Browse this author →KAKEN DB
Kinoshita, Rumiko Browse this author →KAKEN DB
Li, Ruijiang Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Breast cancer
Axillary lymph node metastasis
Magnetic resonance imaging
Diffusion-weighed imaging
Issue Date: Sep-2019
Publisher: Springer
Journal Title: Breast cancer
Volume: 26
Issue: 5
Start Page: 628
End Page: 636
Publisher DOI: 10.1007/s12282-019-00969-0
PMID: 30937834
Abstract: Background We investigated the usefulness of the minimum ADC value of primary breast lesions for predicting axillary lymph node (LN) status in luminal A-like breast cancers with clinically negative nodes in comparison with the mean ADC. Methods Forty-four luminal A-like breast cancers without axillary LN metastasis at preoperative clinical evaluation, surgically resected with sentinel LN biopsy, were retrospectively studied. Mean and minimum ADC values of each lesion were measured and statistically compared between LN positive (n = 12) and LN negative (n = 32) groups. An ROC curve was drawn to determine the best cutoff value to differentiate LN status. Correlations between mean and minimum ADC values and the number of metastatic axillary LNs were investigated. Results Mean and minimum ADC values of breast lesions with positive LN were significantly lower than those with negative LN (mean 839.9 +/- 110.9 vs. 1022.2 +/- 250.0 x 10(- 6) mm(2)/s, p = 0.027, minimum 696.7 +/- 128.0 vs. 925.0 +/- 257.6 x 10(- 6) mm(2)/s, p = 0.004). The sensitivity and NPV using the best cutoff value from ROC using both mean and minimum ADC were 100%. AUC of the minimum ADC (0.784) was higher than that of the mean ADC (0.719). Statistically significant negative correlations were observed between both mean and minimum ADCs and number of positive LNs, with stronger correlation to minimum ADC than mean ADC. Conclusions The minimum ADC value of primary breast lesions predicts axillary LN metastasis in luminal A-like breast cancer with clinically negative nodes, with high sensitivity and high NPV.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Breast cancer. The final authenticated version is available online at: https://doi.org/10.1007/s12282-019-00969-0
Type: article (author version)
URI: http://hdl.handle.net/2115/79147
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 扶美

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