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Quantitative power Doppler signal assessment in the subchondral bone region of the metacarpophalangeal joint is an effective predictor of radiographic progression in the hand of rheumatoid arthritis: a pilot study

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/79158

Title: Quantitative power Doppler signal assessment in the subchondral bone region of the metacarpophalangeal joint is an effective predictor of radiographic progression in the hand of rheumatoid arthritis: a pilot study
Authors: Fujimori, Motoshi Browse this author
Kamishima, Tamotsu Browse this author →KAKEN DB
Narita, Akihiro Browse this author
Henmi, Mihoko Browse this author
Kato, Masaru Browse this author →KAKEN DB
Sutherland, Kenneth Browse this author →KAKEN DB
Nishida, Mutsumi Browse this author →KAKEN DB
Tanaka, Yuki Browse this author →KAKEN DB
Yutong, Lu Browse this author
Tanimura, Kazuhide Browse this author
Atsumi, Tatsuya Browse this author →KAKEN DB
Keywords: Arthritis
Ultrasonography
Hand
Bone
Synovitis
Radiography
Issue Date: Aug-2019
Publisher: Springer
Journal Title: Rheumatology international
Volume: 39
Issue: 8
Start Page: 1413
End Page: 1421
Publisher DOI: 10.1007/s00296-019-04320-w
PMID: 31089859
Abstract: Ultrasonography is useful for assessment of synovitis in the hand of rheumatoid arthritis (RA) patients. The aim of this study was to investigate the predictive value of the quantitative power Doppler (PD) signal assessment in the subchondral bone region of the metacarpophalangeal (MCP) joint in patients with RA showing radiographic progression of the hand by comparing with those of previously reported scoring systems. Twenty-two patients (20 women) with RA who underwent power Doppler ultrasonography (PDUS) of the bilateral one to five MCP joints at baseline were included in the study. Radiography of both hands was performed at baseline and at 1year. PDUS of the synovial space was evaluated according to semi-quantitative scoring (0-3) and quantitative measurement (0-100%). The PD signal in the subchondral bone region was qualitatively (0, 1) and quantitatively (mm(2)) assessed. The performance of PDUS assessment was compared using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and the risk ratio (RR). As a predictor for radiographic progression, the quantitative PD signal assessment in the subchondral bone region (AUC=0.842, p<0.01) was equivalent to quantitative vascularity (AUC=0.817, p<0.05) and semi-quantitative scoring (AUC=0.754, p<0.05). As for the RR of the PD signal in the subchondral bone region for radiographic progression, the quantitative PD signal assessment was 5.40 (p<0.01), whereas the qualitative PD signal assessment was 1.60 (p=0.204). Quantitative PD signal assessment in the subchondral bone region can predict radiographic progression in the hand of RA patients.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/79158
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 神島 保

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