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Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice

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Title: Profiling of cellular immune responses to Mycoplasma pulmonis infection in C57BL/6 and DBA/2 mice
Authors: Boonyarattanasoonthorn, Tussapon Browse this author
Elewa, Yaser Hosny Ali Browse this author
Tag-El-Din-Hassan, Hassan T. Browse this author
Morimatsu, Masami Browse this author →KAKEN DB
Agui, Takashi Browse this author →KAKEN DB
Keywords: Mycoplasma pulmonis
Cellular immune response
Inbred mouse
Issue Date: Sep-2019
Publisher: Elsevier
Journal Title: Infection, Genetics and Evolution
Volume: 73
Start Page: 55
End Page: 65
Publisher DOI: 10.1016/j.meegid.2019.04.019
Abstract: Mycoplasma infections cause respiratory tract damages and atypical pneumonia, resulting in serious problems in humans and animals worldwide. It is well known that laboratory inbred mouse strains show various susceptibility to Mycoplasma pulmonis (M. pulmonis) infection, which causes murine respiratory mycoplasmosis. In this study, we aimed to demonstrate the difference in cellular immune responses between resistant strain, C57BL/6NCrSlc (B6) and susceptible strain, DBA/2CrSlc (D2) after challenging M. pulmonis infection. D2 mice showed higher amount of bacterial proliferation in lung, higher pulmonary infiltration of immune cells such as neutrophils, macrophages, and lymphocytes, and higher levels of interleukin (IL)-1 beta, IL-6, IL-17A, and tumor necrosis factor-alpha in bronchoalveolar lavage fluid than did B6 mice. The results of this study suggest that D2 mice are more susceptible than B6 mice to M. pulmonis infection due to a hyper-immune inflammatory response.
Rights: ©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 安居院 高志

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